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40 changes: 21 additions & 19 deletions tutorial/README.md
Original file line number Diff line number Diff line change
Expand Up @@ -6,44 +6,46 @@ The initial exposition draws on a book chapter by [Sigworth (1995a)](https://doi
To view the notebooks, use the GitHub or nbviewer links below, or clone the repository and run Jupyter notebook locally.
Running locally will require the dependencies from `requirements.txt`.

A list of references and further reading is provided [here](./references.ipynb).
[↩ Back to the main repository](https://github.com/CardiacModelling/VoltageClampModel)

[↩ Back to the main repository](https://github.com/CardiacModelling/VoltageClampModel-new)


## Modelling patch-clamp experiments
## 1. Modelling patch-clamp experiments
[![github](./img/github.svg)](./1-modelling-patch-clamp.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel-new/tree/main/tutorial/1-modelling-patch-clamp.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel/tree/main/tutorial/1-modelling-patch-clamp.ipynb)

The first notebook describes the uncompensated patch-clamp set up, and derives an ODE model from the electrical schematics.

## Modelling electronic compensation
## 2. Modelling electronic compensation
[![github](./img/github.svg)](./2-compensation.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel-new/tree/main/tutorial/2-compensation.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel/tree/main/tutorial/2-compensation.ipynb)

The model is updated to include the compensation circuitry commonly used in patch-clamp amplifiers.

## Simulating a manual patch clamp experiment
## 3. Simulating a manual patch clamp experiment
[![github](./img/github.svg)](./3-simulations.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel-new/tree/main/tutorial/3-simulations.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel/tree/main/tutorial/3-simulations.ipynb)

We walk through and simulate the early steps of a manual patch-clamp experiment.

## Simplified models
## 4. Simplified models
[![github](./img/github.svg)](./4-simplifications.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel-new/tree/main/tutorial/4-simplifications.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel/tree/main/tutorial/4-simplifications.ipynb)

In the final notebook, we derive simplified models and compare with previous work.

---
## Resources

- [![github](./img/github.svg)](./symbols.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel/tree/main/tutorial/symbols.ipynb)
**Names and symbols** A table of all symbols, their meanings, and names used in other publications.

## Appendices
- [![github](./img/github.svg)](./tour.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel/tree/main/tutorial/tour.ipynb)
**Default parameter values** and comments on how to reparameterise the model, are given in the Model Tour.

Finally, there are several appendices:
- [![github](./img/github.svg)](./references.ipynb)
[![nbviewer](./img/nbviewer.svg)](https://nbviewer.jupyter.org/github/CardiacModelling/VoltageClampModel/tree/main/tutorial/references.ipynb)
**References** and further reading.

- [Appendix A](./appendix-a/README.md) adds details on electronics and filters.
- [Appendix B](./appendix-b/README.md) looks at details of the model derivation.
- [Appendix C](./appendix-c/README.md) provides default parameter values, and amplifier-specific ones.
- [Appendix D](./appendix-d/README.md) discusses remaining sources of error.
- [Appendix E](./appendix-e/README.md) looks at Rs and Cm estimates.
Finally, there are [several appendices](./appendix), which provide background on electronics and details of the model derivation.

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