diff --git a/src/Http/Middleware/CP/BootPreferences.php b/src/Http/Middleware/CP/BootPreferences.php
index a02d7dab2c..c0fbd381d3 100644
--- a/src/Http/Middleware/CP/BootPreferences.php
+++ b/src/Http/Middleware/CP/BootPreferences.php
@@ -9,6 +9,10 @@ class BootPreferences
 {
     public function handle($request, Closure $next)
     {
+        if (! $request->inertia() && $request->ajax()) {
+            return $next($request);
+        }
+
         Preference::boot();
 
         return $next($request);
diff --git a/src/Http/Middleware/CP/BootUtilities.php b/src/Http/Middleware/CP/BootUtilities.php
index 0307fa2ea8..1b0e228ee9 100644
--- a/src/Http/Middleware/CP/BootUtilities.php
+++ b/src/Http/Middleware/CP/BootUtilities.php
@@ -9,6 +9,10 @@ class BootUtilities
 {
     public function handle($request, Closure $next)
     {
+        if (! $request->inertia() && $request->ajax()) {
+            return $next($request);
+        }
+
         Utility::boot();
 
         return $next($request);
diff --git a/src/Http/Middleware/CP/ContactOutpost.php b/src/Http/Middleware/CP/ContactOutpost.php
index 33c7d1f4f7..01bb32050a 100644
--- a/src/Http/Middleware/CP/ContactOutpost.php
+++ b/src/Http/Middleware/CP/ContactOutpost.php
@@ -16,6 +16,10 @@ public function __construct(Outpost $outpost)
 
     public function handle($request, Closure $next)
     {
+        if (! $request->inertia() && $request->ajax()) {
+            return $next($request);
+        }
+
         $this->outpost->radio();
 
         return $next($request);
diff --git a/src/Http/Middleware/CP/CountUsers.php b/src/Http/Middleware/CP/CountUsers.php
index 65fd2a30fa..473bae5648 100644
--- a/src/Http/Middleware/CP/CountUsers.php
+++ b/src/Http/Middleware/CP/CountUsers.php
@@ -11,6 +11,10 @@ class CountUsers
 {
     public function handle($request, Closure $next, $guard = null)
     {
+        if (! $request->inertia() && $request->ajax()) {
+            return $next($request);
+        }
+
         if (! Statamic::pro() && User::count() > 1) {
             throw new StatamicProRequiredException('Statamic Pro is required for multiple users.');
         }
diff --git a/src/Http/Middleware/CP/HandleAuthenticatedInertiaRequests.php b/src/Http/Middleware/CP/HandleAuthenticatedInertiaRequests.php
index ba832c8b8f..6458a14d39 100644
--- a/src/Http/Middleware/CP/HandleAuthenticatedInertiaRequests.php
+++ b/src/Http/Middleware/CP/HandleAuthenticatedInertiaRequests.php
@@ -19,6 +19,10 @@ class HandleAuthenticatedInertiaRequests
 {
     public function handle(Request $request, Closure $next)
     {
+        if (! $request->inertia() && $request->ajax()) {
+            return $next($request);
+        }
+
         Inertia::share($this->share($request));
 
         return $next($request);
diff --git a/src/Http/Middleware/CP/HandleInertiaRequests.php b/src/Http/Middleware/CP/HandleInertiaRequests.php
index 5d6f0f3ce4..780d8ed694 100644
--- a/src/Http/Middleware/CP/HandleInertiaRequests.php
+++ b/src/Http/Middleware/CP/HandleInertiaRequests.php
@@ -2,6 +2,7 @@
 
 namespace Statamic\Http\Middleware\CP;
 
+use Closure;
 use Illuminate\Http\Request;
 use Inertia\Middleware;
 use Statamic\CP\Toasts\Manager;
@@ -21,6 +22,15 @@ public function __construct(private Manager $toasts)
         //
     }
 
+    public function handle(Request $request, Closure $next)
+    {
+        if (! $request->inertia() && $request->ajax()) {
+            return $next($request);
+        }
+
+        return parent::handle($request, $next);
+    }
+
     public function share(Request $request): array
     {
         return array_filter([
diff --git a/src/Http/Middleware/DeleteTemporaryFileUploads.php b/src/Http/Middleware/DeleteTemporaryFileUploads.php
index 50e18b0734..ca5f30b683 100644
--- a/src/Http/Middleware/DeleteTemporaryFileUploads.php
+++ b/src/Http/Middleware/DeleteTemporaryFileUploads.php
@@ -9,6 +9,10 @@ class DeleteTemporaryFileUploads
 {
     public function handle($request, Closure $next)
     {
+        if (! $request->inertia() && $request->ajax()) {
+            return $next($request);
+        }
+
         $lottery = [2, 100];
 
         if (random_int(1, $lottery[1]) <= $lottery[0]) {
diff --git a/src/Http/Middleware/RedirectIfTwoFactorSetupIncomplete.php b/src/Http/Middleware/RedirectIfTwoFactorSetupIncomplete.php
index 2692397288..1cd2cd5fae 100644
--- a/src/Http/Middleware/RedirectIfTwoFactorSetupIncomplete.php
+++ b/src/Http/Middleware/RedirectIfTwoFactorSetupIncomplete.php
@@ -10,6 +10,10 @@ class RedirectIfTwoFactorSetupIncomplete
 {
     public function handle(Request $request, Closure $next)
     {
+        if (! $request->inertia() && $request->ajax()) {
+            return $next($request);
+        }
+
         if (
             ($user = User::fromUser($request->user()))
             && $user->isTwoFactorAuthenticationRequired()