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src/content/Competitive.tsx

Lines changed: 29 additions & 29 deletions
Original file line numberDiff line numberDiff line change
@@ -51,11 +51,10 @@ export const competitiveArray: PageContent[] = [
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title: "Competitive Binding",
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content: (
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<>
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We now know the binding affinity of <A /> and <B />. Our
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competitive inhibitor, <D />, also binds to <A /> and we want to
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figure out how effective it is at blocking the binding of <B />.
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We cannot directly measure the formation of <AD /> (which is why
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it's shown in grey).
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In the "High Affinity" section we determined the binding
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affinity of <A /> and <B />. Our new competitive inhibitor,{" "}
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<D />, also binds to <A />. Once it binds to <A />, <B /> can no
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longer bind.
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</>
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),
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layout: LayoutType.LiveSimulation,
@@ -64,54 +63,56 @@ export const competitiveArray: PageContent[] = [
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callToAction:
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"Press play and watch the how the two different complexes form over time.",
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},
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{
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title: "Start the experiment",
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content: (
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<>
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Now, let's use this simulation to make measurements. We'll start
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with [<D />] = 0 so we can get the formation of <AB /> without
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any competition.
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We cannot directly measure the formation of <AD /> (which is why
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it's shown in grey). To figure out how strongly <B /> binds to{" "}
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<A /> we're going to keep track of how adding more <D />{" "}
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decreases the formation of <AB />.
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</>
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),
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layout: LayoutType.LiveSimulation,
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section: Section.Introduction,
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actionButton: <StartExperiment />,
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progressionElement: START_EXPERIMENT_ID,
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callToAction: (
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<>
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Click the <strong>Start experiment</strong> button to reset the
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simulation and begin by pressing <strong>play</strong>!
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</>
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),
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section: Section.Introduction,
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layout: LayoutType.LiveSimulation,
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progressionElement: START_EXPERIMENT_ID,
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},
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{
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title: "Start the experiment",
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content: (
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<>
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Now, let's use this simulation to make measurements. We'll start
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with [<D />] = 0 so we can get the formation of <AB /> without
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any competition.
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We cannot directly measure the formation of <AD /> (which is why
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it's shown in grey). To figure out how strongly <B /> binds to{" "}
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<A /> we're going to keep track of how adding more <D /> affects
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the amount of <AB /> formed.
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</>
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),
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layout: LayoutType.LiveSimulation,
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section: Section.Introduction,
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actionButton: <StartExperiment />,
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progressionElement: PLAY_BUTTON_ID,
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callToAction: (
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<>
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Click the <strong>Start experiment</strong> button to reset the
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simulation and begin by pressing <strong>play</strong>!
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</>
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),
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section: Section.Experiment,
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layout: LayoutType.LiveSimulation,
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progressionElement: PLAY_BUTTON_ID,
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},
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{
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title: "Find maximum complex formation",
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content: (
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<>
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With [<D />] = 0, the <AB /> complex is able to form without any
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inhibition. This will be our baseline for the max amount of{" "}
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<AB /> that can form at these concentrations.{" "}
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We are starting with [<D />] = 0, so the <AB /> complex is able
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to form without any inhibition. This will be our baseline for
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the max amount of <AB /> that can form at these concentrations.{" "}
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</>
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),
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callToAction: (
@@ -130,7 +131,7 @@ export const competitiveArray: PageContent[] = [
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title: "Introduce the competitive inhibitor",
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content: (
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<>
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Now let's see how the addition of <D /> affects the formation of{" "}
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Now let's see how the addition of <D /> effects the formation of{" "}
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<AB />.
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</>
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),
@@ -151,10 +152,10 @@ export const competitiveArray: PageContent[] = [
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title: "Repeating the experiment",
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content: (
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<>
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We want to understand the effect
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<D /> has on the formation of <AB />. Let’s repeat the
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experiment with a new concentration of <D />. We will keep the
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concentration of <A /> and <B /> constant.
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We want to understand the affect <D /> has on the formation of{" "}
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<AB />. Let’s repeat the experiment with a new concentration of{" "}
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<D />. We will keep the concentration of <A /> and <B />{" "}
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constant.
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</>
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),
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callToAction: (
@@ -175,8 +176,7 @@ export const competitiveArray: PageContent[] = [
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The constant K<sub>i</sub> is analogous to K<sub>d</sub> for
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inhibitors. K<sub>i</sub> can be determined in this experiment
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by finding the IC<sub>50</sub>, the concentration of inhibitor
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where the amount of
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<AB /> complex is reduced by half.
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where the amount of <AB /> complex is reduced by half.
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</>
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),
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moreInfo: (
@@ -197,7 +197,7 @@ export const competitiveArray: PageContent[] = [
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},
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{
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content:
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"Congratulations, you’ve completed the High Affinity experiment!",
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"Congratulations, you’ve completed the Competitive Binding experiment!",
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backButton: true,
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// nextButton: true,
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nextButtonText: "View examples",

src/content/LowAffinity.tsx

Lines changed: 1 addition & 1 deletion
Original file line numberDiff line numberDiff line change
@@ -59,7 +59,7 @@ export const lowAffinityContentArray: PageContent[] = [
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},
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{
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content:
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"Congratulations, you’ve completed the High Affinity experiment!",
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"Congratulations, you’ve completed the Low Affinity experiment!",
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backButton: true,
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// nextButton: true,
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nextButtonText: "View examples",

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