diff --git a/src/spatialdata_plot/pl/_validate.py b/src/spatialdata_plot/pl/_validate.py
index 61e8f639..a979ad02 100644
--- a/src/spatialdata_plot/pl/_validate.py
+++ b/src/spatialdata_plot/pl/_validate.py
@@ -96,6 +96,8 @@ def _validate_show_parameters(
     dpi: int | None,
     fig: Figure | None,
     title: list[str] | str | None,
+    xlabel: str | None,
+    ylabel: str | None,
     pad_extent: int | float,
     ax: list[Axes] | Axes | None,
     return_ax: bool,
@@ -183,6 +185,10 @@ def _validate_show_parameters(
     if title is not None and not isinstance(title, list | str):
         raise TypeError("Parameter 'title' must be a string or a list of strings.")
 
+    for _name, _val in (("xlabel", xlabel), ("ylabel", ylabel)):
+        if _val is not None and not isinstance(_val, str):
+            raise TypeError(f"Parameter '{_name}' must be a string or None.")
+
     if not isinstance(pad_extent, int | float):
         raise TypeError("Parameter 'pad_extent' must be numeric.")
 
diff --git a/src/spatialdata_plot/pl/basic.py b/src/spatialdata_plot/pl/basic.py
index a755ccfc..b910671c 100644
--- a/src/spatialdata_plot/pl/basic.py
+++ b/src/spatialdata_plot/pl/basic.py
@@ -1315,6 +1315,8 @@ def show(
         dpi: int | None = None,
         fig: Figure | None = None,
         title: list[str] | str | None = None,
+        xlabel: str | None = None,
+        ylabel: str | None = None,
         pad_extent: int | float = 0,
         ax: list[Axes] | Axes | None = None,
         return_ax: bool = False,
@@ -1378,6 +1380,10 @@ def show(
             Title(s) for the plot. A single string is applied to all panels; a list must match the number
             of panels. If ``None``, each panel is titled with its coordinate system name, or, in multi-panel
             color mode, with its color key.
+        xlabel : str | None, default None
+            Label for the x axis, applied to every rendered panel. ``None`` leaves it unlabelled.
+        ylabel : str | None, default None
+            Label for the y axis, applied to every rendered panel. ``None`` leaves it unlabelled.
         pad_extent : int | float, default 0
             Padding added around the computed spatial extent on all sides.
         ax : list[Axes] | Axes | None
@@ -1440,6 +1446,8 @@ def show(
             dpi=dpi,
             fig=fig,
             title=title,
+            xlabel=xlabel,
+            ylabel=ylabel,
             pad_extent=pad_extent,
             ax=ax,
             return_ax=return_ax,
@@ -1565,6 +1573,8 @@ def show(
                 axis_channel_legend_entries=axis_channel_legend_entries,
                 cs_row=cs_row,
                 title=title,
+                xlabel=xlabel,
+                ylabel=ylabel,
                 dpi=dpi,
                 figsize=figsize,
             )
@@ -1982,15 +1992,18 @@ def _finalize_panel(
     ax: Axes,
     panel_idx: int,
     title: list[str] | None,
+    xlabel: str | None,
+    ylabel: str | None,
     panel_key: str | None,
     cs: str,
     frameon: bool | None,
 ) -> None:
-    """Set a panel's title, equal aspect ratio and frame visibility.
+    """Set a panel's title, axis labels, equal aspect ratio and frame visibility.
 
     With no explicit ``title`` the panel is labelled with its color key (multi-panel color mode)
     or its coordinate-system name; a single-element list applies to every panel, otherwise the
-    title at ``panel_idx`` is used.
+    title at ``panel_idx`` is used. ``xlabel``/``ylabel`` are applied to every panel; ``None``
+    leaves the respective axis unlabelled.
     """
     if title is None:
         t = panel_key if panel_key is not None else cs
@@ -2000,6 +2013,10 @@ def _finalize_panel(
         # len(title) == num_panels is guaranteed by the up-front check in show().
         t = title[panel_idx]
     ax.set_title(t)
+    if xlabel is not None:
+        ax.set_xlabel(xlabel)
+    if ylabel is not None:
+        ax.set_ylabel(ylabel)
     ax.set_aspect("equal")
     if frameon is False:
         ax.axis("off")
@@ -2056,6 +2073,8 @@ def _render_panel(
     axis_channel_legend_entries: list[ChannelLegendEntry],
     cs_row: pd.Series,
     title: list[str] | None,
+    xlabel: str | None,
+    ylabel: str | None,
     dpi: int | None,
     figsize: tuple[float, float] | None,
 ) -> tuple[list[str], dict[str, bool]]:
@@ -2124,5 +2143,5 @@ def _render_panel(
                 _RENDERERS[cmd](**kwargs)
 
     # Panel finalization depends only on per-panel values, so run it once after the loop.
-    _finalize_panel(ax, panel_idx, title, panel_key, cs, fig_params.frameon)
+    _finalize_panel(ax, panel_idx, title, xlabel, ylabel, panel_key, cs, fig_params.frameon)
     return wanted_elements, wants
diff --git a/tests/_images/Show_xlabel_ylabel.png b/tests/_images/Show_xlabel_ylabel.png
new file mode 100644
index 00000000..662ea063
Binary files /dev/null and b/tests/_images/Show_xlabel_ylabel.png differ
diff --git a/tests/pl/test_show.py b/tests/pl/test_show.py
index 455c8661..1582560b 100644
--- a/tests/pl/test_show.py
+++ b/tests/pl/test_show.py
@@ -29,6 +29,10 @@ class TestShow(PlotTester, metaclass=PlotTesterMeta):
     def test_plot_pad_extent_adds_padding(self, sdata_blobs: SpatialData):
         sdata_blobs.pl.render_images(element="blobs_image").pl.show(pad_extent=100)
 
+    def test_plot_xlabel_ylabel(self, sdata_blobs: SpatialData):
+        """Visual test: xlabel/ylabel label the axes (feature for #763)."""
+        sdata_blobs.pl.render_images(element="blobs_image").pl.show(xlabel="x (µm)", ylabel="y (µm)")
+
     def test_plot_frameon_false_single_panel(self, sdata_blobs: SpatialData):
         """Visual test: frameon=False hides axes decorations on a single panel (regression for #204)."""
         sdata_blobs.pl.render_images(element="blobs_image").pl.show(frameon=False)
@@ -172,6 +176,41 @@ def test_title_count_validation(sdata_blobs: SpatialData):
     plt.close("all")
 
 
+def test_xlabel_ylabel(sdata_blobs: SpatialData):
+    """xlabel/ylabel set the axis labels on every panel; None keeps them empty (feature for #763)."""
+    base = sdata_blobs.pl.render_images(element="blobs_image")
+
+    ax = base.pl.show(return_ax=True, show=False)  # default: no labels
+    assert ax.get_xlabel() == "" and ax.get_ylabel() == ""
+    plt.close("all")
+
+    ax = base.pl.show(xlabel="x (µm)", ylabel="y (µm)", return_ax=True, show=False)
+    assert ax.get_xlabel() == "x (µm)" and ax.get_ylabel() == "y (µm)"
+    plt.close("all")
+
+    ax = base.pl.show(xlabel="µm", return_ax=True, show=False)  # one axis only
+    assert ax.get_xlabel() == "µm" and ax.get_ylabel() == ""
+    plt.close("all")
+
+    # broadcast to every panel of a multi-panel plot
+    set_transformation(sdata_blobs["blobs_image"], Identity(), "second_cs")
+    axs = sdata_blobs.pl.render_images(element="blobs_image").pl.show(
+        xlabel="µm", ylabel="µm", return_ax=True, show=False
+    )
+    assert all(a.get_xlabel() == "µm" and a.get_ylabel() == "µm" for a in axs)
+    plt.close("all")
+
+
+def test_xlabel_ylabel_validation(sdata_blobs: SpatialData):
+    """xlabel/ylabel must each be a string or None (feature for #763)."""
+    base = sdata_blobs.pl.render_images(element="blobs_image")
+    with pytest.raises(TypeError, match="xlabel"):
+        base.pl.show(xlabel=1, show=False)
+    with pytest.raises(TypeError, match="ylabel"):
+        base.pl.show(ylabel=("y",), show=False)
+    plt.close("all")
+
+
 def test_fig_parameter_warns_with_ax_list(sdata_blobs: SpatialData):
     """Passing fig= alongside a list of axes should also emit the deprecation (regression for #625)."""
     set_transformation(sdata_blobs["blobs_image"], Identity(), "second_cs")