diff --git a/.github/generate-sbom.py b/.github/generate-sbom.py
index 3b15a7d918e..e0324d1429e 100755
--- a/.github/generate-sbom.py
+++ b/.github/generate-sbom.py
@@ -356,6 +356,45 @@ def generate(version: str) -> dict:
             "scope": "optional",
             "description": "TIFF codec (optional).",
             "licenses": [{"license": {"id": "libtiff"}}],
+            "pedigree": {
+                "ancestors": [
+                    {
+                        "bom-ref": "pkg:generic/libtiff@4.7.1#upstream",
+                        "type": "library",
+                        "name": "libtiff",
+                        "version": "4.7.1",
+                        "purl": "pkg:generic/libtiff@4.7.1",
+                        "externalReferences": [
+                            {
+                                "type": "distribution",
+                                "url": "https://gitlab.com/libtiff/libtiff/-/tags/v4.7.1",
+                            }
+                        ],
+                    }
+                ],
+                "patches": [
+                    {
+                        "type": "cherry-pick",
+                        "diff": {
+                            "text": {
+                                # apply https://gitlab.com/libtiff/libtiff/-/commit/782a11d6
+                                "content": base64.b64encode(
+                                    (
+                                        Path(__file__).parent.parent
+                                        / "patches"
+                                        / "tiff-4.7.1.tar.gz.patch"
+                                    ).read_bytes()
+                                ).decode(),
+                                "encoding": "base64",
+                            }
+                        },
+                    },
+                ],
+                "notes": (
+                    "Vendored from upstream libtiff v4.7.1 with a commit from master "
+                    "cherry-picked to fix CVE-2026-4775."
+                ),
+            },
             "externalReferences": [
                 {"type": "website", "url": "https://libtiff.gitlab.io/libtiff/"},
                 {
diff --git a/.github/workflows/wheels-dependencies.sh b/.github/workflows/wheels-dependencies.sh
index 12593b3f564..8f47b3dea6a 100755
--- a/.github/workflows/wheels-dependencies.sh
+++ b/.github/workflows/wheels-dependencies.sh
@@ -19,6 +19,7 @@ function check_cibw_archs {
 # potential cross-build platforms before native platforms to ensure that we pick
 # up the cross environment.
 PROJECTDIR=$(pwd)
+PATCH_DIR=$(pwd)/patches
 if [[ "$CIBW_PLATFORM" == "ios" ]]; then
     check_cibw_archs
     # On iOS, CIBW_ARCHS is actually a multi-arch - arm64_iphoneos,
diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 5ee040297fb..3ce0922535f 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -21,7 +21,7 @@ repos:
     rev: v1.5.6
     hooks:
       - id: remove-tabs
-        exclude: (Makefile$|\.bat$|\.cmake$|\.eps$|\.fits$|\.gd$|\.opt$)
+        exclude: (Makefile$|\.bat$|\.cmake$|\.eps$|\.fits$|\.gd$|\.opt$|\.patch$)
 
   - repo: https://github.com/pre-commit/mirrors-clang-format
     rev: v22.1.4
@@ -47,11 +47,11 @@ repos:
       - id: check-yaml
         args: [--allow-multiple-documents]
       - id: end-of-file-fixer
-        exclude: ^Tests/images/
+        exclude: ^Tests/images/|\.patch$
       - id: file-contents-sorter
         files: .github/workflows/Brewfile
       - id: trailing-whitespace
-        exclude: ^\.github/.*TEMPLATE|^Tests/(fonts|images)/
+        exclude: ^\.github/.*TEMPLATE|^Tests/(fonts|images)/|\.patch$
 
   - repo: https://github.com/python-jsonschema/check-jsonschema
     rev: 0.37.2
diff --git a/MANIFEST.in b/MANIFEST.in
index d4623a4a8e5..6623f227d60 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -15,6 +15,7 @@ include tox.ini
 graft Tests
 graft Tests/images
 graft checks
+graft patches
 graft src
 graft depends
 graft winbuild
diff --git a/patches/README.md b/patches/README.md
new file mode 100644
index 00000000000..ff4a8f0994f
--- /dev/null
+++ b/patches/README.md
@@ -0,0 +1,14 @@
+Although we try to use official sources for dependencies, sometimes the official
+sources don't support a platform (especially mobile platforms), or there's a bug
+fix/feature that is required to support Pillow's usage.
+
+This folder contains patches that must be applied to official sources, organized
+by the platforms that need those patches.
+
+Each patch is against the root of the unpacked official tarball, and is named by
+appending `.patch` to the end of the tarball that is to be patched. This
+includes the full version number; so if the version is bumped, the patch will
+at a minimum require a filename change.
+
+Wherever possible, these patches should be contributed upstream, in the hope that
+future Pillow versions won't need to maintain these patches.
diff --git a/patches/tiff-4.7.1.tar.gz.patch b/patches/tiff-4.7.1.tar.gz.patch
new file mode 100644
index 00000000000..e7a88cadcbf
--- /dev/null
+++ b/patches/tiff-4.7.1.tar.gz.patch
@@ -0,0 +1,48 @@
+commit 782a11d6b5b61c6dc21e714950a4af5bf89f023c
+Author: Even Rouault <even.rouault@spatialys.com>
+Date:   Sun Feb 22 23:32:47 2026 +0100
+
+    TIFFReadRGBAImage(): prevent integer overflow and later heap overflow on images with huge width in YCbCr tile decoding functions
+
+    Fixes https://gitlab.com/libtiff/libtiff/-/issues/787
+
+diff --git a/libtiff/tif_getimage.c b/libtiff/tif_getimage.c
+index 4543ddda..fa82d091 100644
+--- libtiff/tif_getimage.c
++++ libtiff/tif_getimage.c
+@@ -2224,7 +2224,7 @@ DECLAREContigPutFunc(putcontig8bitYCbCr44tile)
+     uint32_t *cp1 = cp + w + toskew;
+     uint32_t *cp2 = cp1 + w + toskew;
+     uint32_t *cp3 = cp2 + w + toskew;
+-    int32_t incr = 3 * w + 4 * toskew;
++    const tmsize_t incr = 3 * (tmsize_t)w + 4 * (tmsize_t)toskew;
+
+     (void)y;
+     /* adjust fromskew */
+@@ -2364,7 +2364,7 @@ DECLAREContigPutFunc(putcontig8bitYCbCr44tile)
+ DECLAREContigPutFunc(putcontig8bitYCbCr42tile)
+ {
+     uint32_t *cp1 = cp + w + toskew;
+-    int32_t incr = 2 * toskew + w;
++    const tmsize_t incr = 2 * (tmsize_t)toskew + w;
+
+     (void)y;
+     fromskew = (fromskew / 4) * (4 * 2 + 2);
+@@ -2522,7 +2522,7 @@ DECLAREContigPutFunc(putcontig8bitYCbCr41tile)
+ DECLAREContigPutFunc(putcontig8bitYCbCr22tile)
+ {
+     uint32_t *cp2;
+-    int32_t incr = 2 * toskew + w;
++    const tmsize_t incr = 2 * (tmsize_t)toskew + w;
+     (void)y;
+     fromskew = (fromskew / 2) * (2 * 2 + 2);
+     cp2 = cp + w + toskew;
+@@ -2625,7 +2625,7 @@ DECLAREContigPutFunc(putcontig8bitYCbCr21tile)
+ DECLAREContigPutFunc(putcontig8bitYCbCr12tile)
+ {
+     uint32_t *cp2;
+-    int32_t incr = 2 * toskew + w;
++    const tmsize_t incr = 2 * (tmsize_t)toskew + w;
+     (void)y;
+     fromskew = (fromskew / 1) * (1 * 2 + 2);
+     cp2 = cp + w + toskew;
diff --git a/wheels/multibuild b/wheels/multibuild
index 64739327166..4546f4d4820 160000
--- a/wheels/multibuild
+++ b/wheels/multibuild
@@ -1 +1 @@
-Subproject commit 64739327166fcad1fa41ad9b23fa910fa244c84f
+Subproject commit 4546f4d4820ffd0104b872c3b6187260b3e64edc
diff --git a/winbuild/build_prepare.py b/winbuild/build_prepare.py
index f55c82112ac..b69d1486e0d 100644
--- a/winbuild/build_prepare.py
+++ b/winbuild/build_prepare.py
@@ -213,6 +213,10 @@ def cmd_msbuild(
                 # link against libwebp.lib
                 "#ifdef WEBP_SUPPORT": '#ifdef WEBP_SUPPORT\n#pragma comment(lib, "libwebp.lib")',  # noqa: E501
             },
+            r"libtiff\tif_getimage.c": {
+                "int32_t incr = 3 * w + 4 * toskew;": "const tmsize_t incr = 3 * (tmsize_t)w + 4 * (tmsize_t)toskew;",  # noqa: E501
+                "int32_t incr = 2 * toskew + w;": "const tmsize_t incr = 2 * (tmsize_t)toskew + w;",  # noqa: E501
+            },
         },
         "build": [
             *cmds_cmake(