diff --git a/.github/workflows/pytest.yml b/.github/workflows/pytest.yml
new file mode 100644
index 0000000..8f310b1
--- /dev/null
+++ b/.github/workflows/pytest.yml
@@ -0,0 +1,72 @@
+name: Run Tests
+
+on:
+  pull_request:
+  schedule:
+    - cron: '0 6 * * 1'  # Every Monday at 06:00 UTC
+
+jobs:
+  test:
+    runs-on: ${{ matrix.os }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [ubuntu-latest, macos-latest]
+        python-version: ['3.10', '3.11', '3.12', '3.13']
+        include:
+          # Windows builds require mingw/gcc (MSVC cannot compile the AVX intrinsics).
+          # Use conda + m2w64-toolchain to match the wheel build workflow.
+          - os: windows-latest
+            python-version: '3.10'
+          - os: windows-latest
+            python-version: '3.11'
+          - os: windows-latest
+            python-version: '3.12'
+          - os: windows-latest
+            python-version: '3.13'
+
+    steps:
+      - uses: actions/checkout@v4
+
+      # --- Linux / macOS: plain pip install ---
+      - name: Set up Python ${{ matrix.python-version }} (non-Windows)
+        if: runner.os != 'Windows'
+        uses: actions/setup-python@v5
+        with:
+          python-version: ${{ matrix.python-version }}
+
+      - name: Install build dependencies (non-Windows)
+        if: runner.os != 'Windows'
+        run: pip install meson-python meson ninja numpy cython pytest
+
+      - name: Build and install (non-Windows)
+        if: runner.os != 'Windows'
+        run: pip install . --no-build-isolation
+
+      # --- Windows: conda + mingw so gcc is used instead of MSVC ---
+      - name: Set up conda + Python ${{ matrix.python-version }} (Windows)
+        if: runner.os == 'Windows'
+        uses: conda-incubator/setup-miniconda@v3
+        with:
+          python-version: ${{ matrix.python-version }}
+          auto-activate-base: false
+          activate-environment: test
+
+      - name: Install build dependencies (Windows)
+        if: runner.os == 'Windows'
+        shell: bash -el {0}
+        run: |
+          conda install -y numpy cython libpython m2w64-toolchain
+          pip install meson-python meson ninja pytest
+
+      - name: Build and install (Windows)
+        if: runner.os == 'Windows'
+        shell: bash -el {0}
+        run: |
+          pip install . --no-build-isolation \
+            -Csetup-args="--native-file=${{ github.workspace }}/mingw_native.ini"
+
+      # --- Run tests ---
+      - name: Run tests
+        shell: bash -el {0}
+        run: pytest test_pymecompress.py -v
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
deleted file mode 100644
index ae821c3..0000000
--- a/.github/workflows/test.yml
+++ /dev/null
@@ -1,38 +0,0 @@
-name: Python Package using Conda
-
-on: [push]
-
-jobs:
-  build-linux:
-    runs-on: ubuntu-latest
-    strategy:
-      max-parallel: 5
-
-    steps:
-    - uses: actions/checkout@v3
-    - name: Set up Python 3.8
-      uses: actions/setup-python@v3
-      with:
-        python-version: 3.8
-    - name: Add conda to system path
-      run: |
-        # $CONDA is an environment variable pointing to the root of the miniconda directory
-        echo $CONDA/bin >> $GITHUB_PATH
-    - name: Install dependencies
-      run: |
-        #conda env update --file environment.yml --name base
-        conda install numpy cython
-    - name: Lint with flake8
-      run: |
-        conda install flake8
-        # stop the build if there are Python syntax errors or undefined names
-        flake8 . --count --select=E9,F63,F7,F82 --show-source --statistics
-        # exit-zero treats all errors as warnings. The GitHub editor is 127 chars wide
-        flake8 . --count --exit-zero --max-complexity=10 --max-line-length=127 --statistics
-    - name: Build extensions
-      run: |
-        python setup.py build_ext -i
-    - name: Test with pytest
-      run: |
-        conda install pytest
-        pytest
diff --git a/README.md b/README.md
index 6137325..d5b2b36 100644
--- a/README.md
+++ b/README.md
@@ -1,5 +1,5 @@
 # PYMECompress
-![testing](https://github.com/python-microscocopy/pymecompress/actions/workflows/test.yml/badge.svg)
+![testing](https://github.com/python-microscopy/pymecompress/actions/workflows/pytest.yml/badge.svg)
 ![conda](https://img.shields.io/conda/v/david_baddeley/pymecompress)
 ![pypi](https://img.shields.io/pypi/v/pymecompress)
 ![pyversions](https://img.shields.io/pypi/pyversions/pymecompress)
diff --git a/pyproject.toml b/pyproject.toml
index 37648f2..f0eb4c4 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -21,3 +21,6 @@ classifiers = [
 
 [project.urls]
 "Homepage" = "https://github.com/python-microscopy/pymecompress"
+
+[tool.pytest.ini_options]
+addopts = "--import-mode=importlib"