diff --git a/packages/react-devtools-shared/src/devtools/views/Components/InspectedElementSuspendedBy.js b/packages/react-devtools-shared/src/devtools/views/Components/InspectedElementSuspendedBy.js
index 50186f47b215..ffcdd7df0ca8 100644
--- a/packages/react-devtools-shared/src/devtools/views/Components/InspectedElementSuspendedBy.js
+++ b/packages/react-devtools-shared/src/devtools/views/Components/InspectedElementSuspendedBy.js
@@ -584,6 +584,9 @@ export default function InspectedElementSuspendedBy({
       break;
   }
 
+  if (groups.length === 0) {
+    return null;
+  }
   return (
     <div>
       <div className={styles.HeaderRow}>
diff --git a/packages/react-dom-bindings/src/client/ReactFiberConfigDOM.js b/packages/react-dom-bindings/src/client/ReactFiberConfigDOM.js
index 4cb4e8e4273a..727ec694bbf7 100644
--- a/packages/react-dom-bindings/src/client/ReactFiberConfigDOM.js
+++ b/packages/react-dom-bindings/src/client/ReactFiberConfigDOM.js
@@ -4520,18 +4520,30 @@ export function setFocusIfFocusable(
   //
   // We could compare the node to document.activeElement after focus,
   // but this would not handle the case where application code managed focus to automatically blur.
+  const element = ((node: any): HTMLElement);
+
+  // If this element is already the active element, it's focusable and already
+  // focused. Calling .focus() on it would be a no-op (no focus event fires),
+  // so we short-circuit here.
+  if (element.ownerDocument.activeElement === element) {
+    return true;
+  }
+
   let didFocus = false;
   const handleFocus = () => {
     didFocus = true;
   };
 
-  const element = ((node: any): HTMLElement);
   try {
-    element.addEventListener('focus', handleFocus);
+    // Listen on the document in the capture phase so we detect focus even when
+    // it lands on a different element than the one we called .focus() on. This
+    // happens with <label> elements (focus delegates to the associated input)
+    // and shadow hosts with delegatesFocus.
+    element.ownerDocument.addEventListener('focus', handleFocus, true);
     // $FlowFixMe[method-unbinding]
     (element.focus || HTMLElement.prototype.focus).call(element, focusOptions);
   } finally {
-    element.removeEventListener('focus', handleFocus);
+    element.ownerDocument.removeEventListener('focus', handleFocus, true);
   }
 
   return didFocus;
diff --git a/packages/react-dom/src/__tests__/ReactDOMFragmentRefs-test.js b/packages/react-dom/src/__tests__/ReactDOMFragmentRefs-test.js
index aed4f5252f84..3b702648eff6 100644
--- a/packages/react-dom/src/__tests__/ReactDOMFragmentRefs-test.js
+++ b/packages/react-dom/src/__tests__/ReactDOMFragmentRefs-test.js
@@ -255,6 +255,102 @@ describe('FragmentRefs', () => {
         expect(document.activeElement.id).toEqual('child-b');
         document.activeElement.blur();
       });
+
+      // @gate enableFragmentRefs
+      it('keeps focus on the first focusable child if already focused', async () => {
+        const fragmentRef = React.createRef();
+        const root = ReactDOMClient.createRoot(container);
+
+        function Test() {
+          return (
+            <Fragment ref={fragmentRef}>
+              <a id="child-a" href="/">
+                A
+              </a>
+              <a id="child-b" href="/">
+                B
+              </a>
+            </Fragment>
+          );
+        }
+
+        await act(() => {
+          root.render(<Test />);
+        });
+
+        // Focus the first child manually
+        document.getElementById('child-a').focus();
+        expect(document.activeElement.id).toEqual('child-a');
+
+        // Calling fragment.focus() should keep focus on child-a,
+        // not skip to child-b
+        await act(() => {
+          fragmentRef.current.focus();
+        });
+        expect(document.activeElement.id).toEqual('child-a');
+        document.activeElement.blur();
+      });
+
+      // @gate enableFragmentRefs
+      it('keeps focus on a nested child if already focused', async () => {
+        const fragmentRef = React.createRef();
+        const root = ReactDOMClient.createRoot(container);
+
+        function Test() {
+          return (
+            <Fragment ref={fragmentRef}>
+              <div>
+                <input id="nested-input" />
+              </div>
+              <a id="sibling-link" href="/">
+                Link
+              </a>
+            </Fragment>
+          );
+        }
+
+        await act(() => {
+          root.render(<Test />);
+        });
+
+        // Focus the nested input manually
+        document.getElementById('nested-input').focus();
+        expect(document.activeElement.id).toEqual('nested-input');
+
+        // Calling fragment.focus() should keep focus on nested-input
+        await act(() => {
+          fragmentRef.current.focus();
+        });
+        expect(document.activeElement.id).toEqual('nested-input');
+        document.activeElement.blur();
+      });
+
+      // @gate enableFragmentRefs
+      it('focuses the first focusable child in a fieldset', async () => {
+        const fragmentRef = React.createRef();
+        const root = ReactDOMClient.createRoot(container);
+
+        function Test() {
+          return (
+            <Fragment ref={fragmentRef}>
+              <fieldset>
+                <legend>Shipping</legend>
+                <input id="street" name="street" />
+                <input id="city" name="city" />
+              </fieldset>
+            </Fragment>
+          );
+        }
+
+        await act(() => {
+          root.render(<Test />);
+        });
+        await act(() => {
+          fragmentRef.current.focus();
+        });
+        expect(document.activeElement.id).toEqual('street');
+        document.activeElement.blur();
+      });
     });
 
     describe('focusLast()', () => {