diff --git a/.changes/next-release/bugfix-Configuration-47190.json b/.changes/next-release/bugfix-Configuration-47190.json
new file mode 100644
index 000000000000..a3cfd1350208
--- /dev/null
+++ b/.changes/next-release/bugfix-Configuration-47190.json
@@ -0,0 +1,5 @@
+{
+  "type": "bugfix",
+  "category": "Configuration",
+  "description": "Update ``configure set`` command to return an error when newline or carriage-return characters are specified in the value."
+}
diff --git a/awscli/customizations/configure/writer.py b/awscli/customizations/configure/writer.py
index 8a173ab68673..da47cd2b53b3 100644
--- a/awscli/customizations/configure/writer.py
+++ b/awscli/customizations/configure/writer.py
@@ -24,6 +24,12 @@ class ConfigFileWriter:
         r'(?P<value>.*)$'
     )  # fmt: skip
 
+    def _validate_no_newlines(self, value, label='value'):
+        if isinstance(value, str) and ('\n' in value or '\r' in value):
+            raise ValueError(
+                f"Invalid {label}: newline characters are not allowed: {value!r}"
+            )
+
     def update_config(self, new_values, config_filename):
         """Update config file with new values.
 
@@ -52,6 +58,15 @@ def update_config(self, new_values, config_filename):
 
         """
         section_name = new_values.pop('__section__', 'default')
+        self._validate_no_newlines(section_name, 'section name')
+        for k, v in new_values.items():
+            self._validate_no_newlines(k, 'key')
+            if not isinstance(v, dict):
+                self._validate_no_newlines(v, 'value')
+            else:
+                for sk, sv in v.items():
+                    self._validate_no_newlines(sk, 'key')
+                    self._validate_no_newlines(sv, 'value')
         if not os.path.isfile(config_filename):
             self._create_file(config_filename)
             self._write_new_section(section_name, new_values, config_filename)
diff --git a/tests/functional/configure/test_configure.py b/tests/functional/configure/test_configure.py
index b93c662e4879..c8eed2a5a0b7 100644
--- a/tests/functional/configure/test_configure.py
+++ b/tests/functional/configure/test_configure.py
@@ -299,6 +299,53 @@ def test_get_nested_attribute(self):
         )
         self.assertEqual(stdout, "")
 
+    def test_set_rejects_newline_in_value(self):
+        _, stderr, _ = self.run_cmd(
+            ["configure", "set", "region", "us-east-1\nus-west-2"],
+            expected_rc=255,
+        )
+        self.assertIn("newline", stderr)
+
+    def test_set_rejects_carriage_return_in_value(self):
+        _, stderr, _ = self.run_cmd(
+            ["configure", "set", "region", "us-east-1\rus-west-2"],
+            expected_rc=255,
+        )
+        self.assertIn("newline", stderr)
+
+    def test_set_rejects_newline_in_nested_value(self):
+        _, stderr, _ = self.run_cmd(
+            ["configure", "set", "default.s3.signature_version", "s3v4\nfoo"],
+            expected_rc=255,
+        )
+        self.assertIn("newline", stderr)
+
+    def test_newline_injection_does_not_write_injected_key_to_file(self):
+        # Simulates: aws configure set output $'table\nregion = us-east-1'
+        # The injected key must not appear anywhere in the config file.
+        self.set_config_file_contents("[default]\n")
+        self.run_cmd(
+            ["configure", "set", "output", "table\nregion = us-east-1"],
+            expected_rc=255,
+        )
+        contents = self.get_config_file_contents()
+        self.assertNotIn("region", contents)
+
+    def test_newline_injection_does_not_set_injected_key_in_parsed_config(self):
+        # Even if the file were somehow written, the injected key must not be
+        # readable back via 'configure get'.
+        self.set_config_file_contents("[default]\n")
+        self.run_cmd(
+            ["configure", "set", "output", "table\nregion = us-east-1"],
+            expected_rc=255,
+        )
+        # Re-create the driver so it re-reads the (unchanged) config file.
+        self.driver = create_clidriver()
+        stdout, _, _ = self.run_cmd(
+            "configure get region", expected_rc=1
+        )
+        self.assertEqual(stdout.strip(), "")
+
 
 class TestConfigureHasArgTable(unittest.TestCase):
     def test_configure_command_has_arg_table(self):
diff --git a/tests/unit/customizations/configure/test_writer.py b/tests/unit/customizations/configure/test_writer.py
index ae6a5de49410..a3c62bd30896 100644
--- a/tests/unit/customizations/configure/test_writer.py
+++ b/tests/unit/customizations/configure/test_writer.py
@@ -314,3 +314,39 @@ def test_appends_newline_on_new_section(self):
             '[new-section]\n'
             'region = us-west-2\n',
         )
+
+    def test_newline_in_value_raises(self):
+        with open(self.config_filename, 'w') as f:
+            f.write('[default]\nfoo = bar\n')
+        with self.assertRaises(ValueError):
+            self.writer.update_config({'foo': 'bad\nvalue'}, self.config_filename)
+
+    def test_carriage_return_in_value_raises(self):
+        with open(self.config_filename, 'w') as f:
+            f.write('[default]\nfoo = bar\n')
+        with self.assertRaises(ValueError):
+            self.writer.update_config({'foo': 'bad\rvalue'}, self.config_filename)
+
+    def test_newline_in_key_raises(self):
+        with open(self.config_filename, 'w') as f:
+            f.write('[default]\nfoo = bar\n')
+        with self.assertRaises(ValueError):
+            self.writer.update_config({'bad\nkey': 'value'}, self.config_filename)
+
+    def test_newline_in_section_name_raises(self):
+        with open(self.config_filename, 'w') as f:
+            f.write('[default]\nfoo = bar\n')
+        with self.assertRaises(ValueError):
+            self.writer.update_config(
+                {'foo': 'value', '__section__': 'bad\nsection'},
+                self.config_filename
+            )
+
+    def test_newline_in_nested_value_raises(self):
+        with open(self.config_filename, 'w') as f:
+            f.write('[default]\n')
+        with self.assertRaises(ValueError):
+            self.writer.update_config(
+                {'__section__': 'default', 's3': {'key': 'bad\nvalue'}},
+                self.config_filename
+            )