diff --git a/compiler/rustc_infer/src/infer/mod.rs b/compiler/rustc_infer/src/infer/mod.rs
index 583fb1d7db21a..62fb3370aa9b8 100644
--- a/compiler/rustc_infer/src/infer/mod.rs
+++ b/compiler/rustc_infer/src/infer/mod.rs
@@ -1613,6 +1613,23 @@ impl<'tcx> InferCtxt<'tcx> {
         }
     }
 
+    /// Smallest type vid equated, sub-unified, or instantiated since the last
+    /// [`Self::reset_min_changed_ty_vid`]. Used by next-solver fulfillment to
+    /// skip walking pending goals stalled only on older vids.
+    #[inline]
+    pub fn min_changed_ty_vid(&self) -> Option<u32> {
+        self.inner.borrow().type_variable_storage.min_changed_ty_vid()
+    }
+
+    pub fn reset_min_changed_ty_vid(&self) {
+        self.inner.borrow_mut().type_variables().reset_min_changed_ty_vid();
+    }
+
+    #[inline]
+    pub fn opaque_type_count(&self) -> usize {
+        self.inner.borrow().opaque_type_storage.num_entries().num_opaque_types()
+    }
+
     /// `ty_or_const_infer_var_changed` is equivalent to one of these two:
     ///   * `shallow_resolve(ty) != ty` (where `ty.kind = ty::Infer(_)`)
     ///   * `shallow_resolve(ct) != ct` (where `ct.kind = ty::ConstKind::Infer(_)`)
diff --git a/compiler/rustc_infer/src/infer/opaque_types/table.rs b/compiler/rustc_infer/src/infer/opaque_types/table.rs
index 066d12be320a2..ff2835baa9d20 100644
--- a/compiler/rustc_infer/src/infer/opaque_types/table.rs
+++ b/compiler/rustc_infer/src/infer/opaque_types/table.rs
@@ -30,6 +30,13 @@ impl rustc_type_ir::inherent::OpaqueTypeStorageEntries for OpaqueTypeStorageEntr
     }
 }
 
+impl OpaqueTypeStorageEntries {
+    #[inline]
+    pub fn num_opaque_types(self) -> usize {
+        self.opaque_types
+    }
+}
+
 impl<'tcx> OpaqueTypeStorage<'tcx> {
     #[instrument(level = "debug")]
     pub(crate) fn remove(
diff --git a/compiler/rustc_infer/src/infer/type_variable.rs b/compiler/rustc_infer/src/infer/type_variable.rs
index be0ac72d85675..c00bff1451845 100644
--- a/compiler/rustc_infer/src/infer/type_variable.rs
+++ b/compiler/rustc_infer/src/infer/type_variable.rs
@@ -2,7 +2,7 @@ use std::cmp;
 use std::marker::PhantomData;
 use std::ops::Range;
 
-use rustc_data_structures::undo_log::Rollback;
+use rustc_data_structures::undo_log::{Rollback, UndoLogs};
 use rustc_data_structures::{snapshot_vec as sv, unify as ut};
 use rustc_hir::HirId;
 use rustc_hir::def_id::DefId;
@@ -19,6 +19,8 @@ use crate::infer::InferCtxtUndoLogs;
 pub(crate) enum UndoLog<'tcx> {
     EqRelation(sv::UndoLog<ut::Delegate<TyVidEqKey<'tcx>>>),
     SubRelation(sv::UndoLog<ut::Delegate<TyVidSubKey>>),
+    /// Previous value of [`TypeVariableStorage::min_changed_ty_vid`].
+    MinChangedTyVid(Option<u32>),
 }
 
 /// Convert from a specific kind of undo to the more general UndoLog
@@ -52,6 +54,7 @@ impl<'tcx> Rollback<UndoLog<'tcx>> for TypeVariableStorage<'tcx> {
         match undo {
             UndoLog::EqRelation(undo) => self.eq_relations.reverse(undo),
             UndoLog::SubRelation(undo) => self.sub_unification_table.reverse(undo),
+            UndoLog::MinChangedTyVid(prev) => self.min_changed_ty_vid = prev,
         }
     }
 }
@@ -83,6 +86,12 @@ pub(crate) struct TypeVariableStorage<'tcx> {
     /// type of `x` is only a supertype of the argument of `returns_arg`. We
     /// still want to suggest specifying the type of the argument.
     sub_unification_table: ut::UnificationTableStorage<TyVidSubKey>,
+    /// Smallest type-inference vid that was equated, sub-unified, or
+    /// instantiated since the last [`TypeVariableTable::reset_min_changed_ty_vid`].
+    ///
+    /// Next-solver fulfillment uses this to skip walking pending goals that
+    /// can only become unstalled by changes to older vids (see rustc#159933).
+    min_changed_ty_vid: Option<u32>,
 }
 
 pub(crate) struct TypeVariableTable<'a, 'tcx> {
@@ -161,6 +170,11 @@ impl<'tcx> TypeVariableStorage<'tcx> {
     pub(crate) fn sub_unification_table_ref(&self) -> &ut::UnificationTableStorage<TyVidSubKey> {
         &self.sub_unification_table
     }
+
+    #[inline]
+    pub(crate) fn min_changed_ty_vid(&self) -> Option<u32> {
+        self.min_changed_ty_vid
+    }
 }
 
 impl<'tcx> TypeVariableTable<'_, 'tcx> {
@@ -172,12 +186,37 @@ impl<'tcx> TypeVariableTable<'_, 'tcx> {
         self.storage.values[vid].origin
     }
 
+    fn note_ty_infer_change(&mut self, vid: ty::TyVid) {
+        let idx = vid.as_u32();
+        let old = self.storage.min_changed_ty_vid;
+        let new = Some(old.map_or(idx, |m| m.min(idx)));
+        if old != new {
+            self.undo_log.push(UndoLog::MinChangedTyVid(old));
+            self.storage.min_changed_ty_vid = new;
+        }
+    }
+
+    pub(crate) fn reset_min_changed_ty_vid(&mut self) {
+        let old = self.storage.min_changed_ty_vid;
+        if old.is_some() {
+            self.undo_log.push(UndoLog::MinChangedTyVid(old));
+            self.storage.min_changed_ty_vid = None;
+        }
+    }
+
     /// Records that `a == b`.
     ///
     /// Precondition: neither `a` nor `b` are known.
     pub(crate) fn equate(&mut self, a: ty::TyVid, b: ty::TyVid) {
         debug_assert!(self.probe(a).is_unknown());
         debug_assert!(self.probe(b).is_unknown());
+        let ra = self.root_var(a);
+        let rb = self.root_var(b);
+        let sa = self.sub_unification_table_root_var(a);
+        let sb = self.sub_unification_table_root_var(b);
+        self.note_ty_infer_change(ty::TyVid::from_u32(
+            ra.as_u32().min(rb.as_u32()).min(sa.as_u32()).min(sb.as_u32()),
+        ));
         self.eq_relations().union(a, b);
         self.sub_unification_table().union(a, b);
     }
@@ -189,6 +228,9 @@ impl<'tcx> TypeVariableTable<'_, 'tcx> {
     pub(crate) fn sub_unify(&mut self, a: ty::TyVid, b: ty::TyVid) {
         debug_assert!(self.probe(a).is_unknown());
         debug_assert!(self.probe(b).is_unknown());
+        let sa = self.sub_unification_table_root_var(a);
+        let sb = self.sub_unification_table_root_var(b);
+        self.note_ty_infer_change(if sa.as_u32() < sb.as_u32() { sa } else { sb });
         self.sub_unification_table().union(a, b);
     }
 
@@ -204,6 +246,7 @@ impl<'tcx> TypeVariableTable<'_, 'tcx> {
             "instantiating type variable `{vid:?}` twice: new-value = {ty:?}, old-value={:?}",
             self.eq_relations().probe_value(vid)
         );
+        self.note_ty_infer_change(vid);
         self.eq_relations().union_value(vid, TypeVariableValue::Known { value: ty });
     }
 
diff --git a/compiler/rustc_trait_selection/src/solve/fulfill.rs b/compiler/rustc_trait_selection/src/solve/fulfill.rs
index 549dcc24cfa9a..c52214d251443 100644
--- a/compiler/rustc_trait_selection/src/solve/fulfill.rs
+++ b/compiler/rustc_trait_selection/src/solve/fulfill.rs
@@ -9,7 +9,8 @@ use rustc_infer::traits::{
 use rustc_middle::ty::{self, TyCtxt, TypeVisitableExt, TypingMode};
 use rustc_next_trait_solver::solve::fast_path::compute_goal_fast_path;
 use rustc_next_trait_solver::solve::{
-    GoalEvaluation, GoalStalledOn, HasChanged, SolverDelegateEvalExt as _, StalledOnCoroutines,
+    GoalEvaluation, GoalStalledOn, GoalStalledOnOpaques, HasChanged, SolverDelegateEvalExt as _,
+    StalledOnCoroutines, TyOrConstInferVar,
 };
 use thin_vec::ThinVec;
 use tracing::instrument;
@@ -44,6 +45,15 @@ pub struct FulfillmentCtxt<'tcx, E: 'tcx> {
     /// gets rolled back. Because of this we explicitly check that we only
     /// use the context in exactly this snapshot.
     usable_in_snapshot: usize,
+    /// Whether every pending goal has precise, type-var-only stall info.
+    /// Int/float/const stalls and opaque-count mismatches force a full scan.
+    all_pending_trackable: bool,
+    /// Maximum type vid among pending `stalled_vars` / `sub_roots`.
+    /// Changes to strictly newer vids cannot make these goals unstalled.
+    max_stalled_ty_vid: Option<u32>,
+    /// Shared `GoalStalledOnOpaques::Yes` storage count, if any pending goal
+    /// recorded one. `None` means no pending goal depends on opaques.
+    stalled_opaque_count: Option<usize>,
     _errors: PhantomData<E>,
 }
 
@@ -132,10 +142,118 @@ impl<'tcx, E: 'tcx> FulfillmentCtxt<'tcx, E> {
         FulfillmentCtxt {
             obligations: Default::default(),
             usable_in_snapshot: infcx.num_open_snapshots(),
+            all_pending_trackable: true,
+            max_stalled_ty_vid: None,
+            stalled_opaque_count: None,
             _errors: PhantomData,
         }
     }
 
+    fn reset_tracking(&mut self) {
+        self.all_pending_trackable = true;
+        self.max_stalled_ty_vid = None;
+        self.stalled_opaque_count = None;
+    }
+
+    fn note_registered_stalled_on(&mut self, stalled_on: Option<&GoalStalledOn<TyCtxt<'tcx>>>) {
+        if !self.all_pending_trackable {
+            return;
+        }
+        let Some(stalled_on) = stalled_on else {
+            self.all_pending_trackable = false;
+            return;
+        };
+        if !record_trackable_stalled_on(
+            stalled_on,
+            &mut self.max_stalled_ty_vid,
+            &mut self.stalled_opaque_count,
+        ) {
+            self.all_pending_trackable = false;
+        }
+    }
+
+    fn recompute_tracking(&mut self) {
+        let mut max_stalled_ty_vid = None;
+        let mut stalled_opaque_count = None;
+        let mut all_pending_trackable = true;
+        for (_, stalled_on) in &self.obligations.pending {
+            match stalled_on {
+                Some(stalled_on) => {
+                    if !record_trackable_stalled_on(
+                        stalled_on,
+                        &mut max_stalled_ty_vid,
+                        &mut stalled_opaque_count,
+                    ) {
+                        all_pending_trackable = false;
+                        break;
+                    }
+                }
+                None => {
+                    all_pending_trackable = false;
+                    break;
+                }
+            }
+        }
+        self.all_pending_trackable = all_pending_trackable;
+        self.max_stalled_ty_vid = max_stalled_ty_vid;
+        self.stalled_opaque_count = stalled_opaque_count;
+    }
+
+    /// Skip the pending-queue walk when no pending goal can have been
+    /// unstalled: every goal is trackable, opaque storage is unchanged,
+    /// and every type-infer change is to a newer vid than any stalled vid.
+    fn can_skip_fulfillment(&self, infcx: &InferCtxt<'tcx>) -> bool {
+        if infcx.disable_trait_solver_fast_paths() || !self.all_pending_trackable {
+            return false;
+        }
+        if let Some(n) = self.stalled_opaque_count
+            && infcx.opaque_type_count() != n
+        {
+            return false;
+        }
+        match (infcx.min_changed_ty_vid(), self.max_stalled_ty_vid) {
+            (None, _) | (Some(_), None) => true,
+            (Some(changed), Some(stalled)) => changed > stalled,
+        }
+    }
+}
+
+/// Returns `false` if this stalled goal cannot participate in the
+/// "no relevant type-infer change" fulfillment skip.
+fn record_trackable_stalled_on<'tcx>(
+    stalled_on: &GoalStalledOn<TyCtxt<'tcx>>,
+    max_stalled_ty_vid: &mut Option<u32>,
+    stalled_opaque_count: &mut Option<usize>,
+) -> bool {
+    for var in &stalled_on.stalled_vars {
+        match *var {
+            TyOrConstInferVar::Ty(vid) => {
+                let idx = vid.as_u32();
+                *max_stalled_ty_vid = Some(max_stalled_ty_vid.map_or(idx, |m| m.max(idx)));
+            }
+            TyOrConstInferVar::TyInt(_)
+            | TyOrConstInferVar::TyFloat(_)
+            | TyOrConstInferVar::Const(_) => return false,
+        }
+    }
+    for &vid in &stalled_on.sub_roots {
+        let idx = vid.as_u32();
+        *max_stalled_ty_vid = Some(max_stalled_ty_vid.map_or(idx, |m| m.max(idx)));
+    }
+    match stalled_on.opaques {
+        GoalStalledOnOpaques::No => true,
+        GoalStalledOnOpaques::Yes { num_opaques_in_storage, .. } => match stalled_opaque_count {
+            None => {
+                *stalled_opaque_count = Some(num_opaques_in_storage);
+                true
+            }
+            Some(n) if *n == num_opaques_in_storage => true,
+            Some(_) => false,
+        },
+    }
+}
+
+impl<'tcx, E: 'tcx> FulfillmentCtxt<'tcx, E> {
     fn inspect_evaluated_obligation(
         infcx: &InferCtxt<'tcx>,
         obligation: &PredicateObligation<'tcx>,
@@ -172,10 +290,12 @@ where
             match certainty {
                 Certainty::Yes => {}
                 Certainty::Maybe(_) => {
+                    self.note_registered_stalled_on(stalled_on.as_ref());
                     self.obligations.register(obligation, stalled_on);
                 }
             }
         } else {
+            self.note_registered_stalled_on(None);
             self.obligations.register(obligation, None);
         }
     }
@@ -193,6 +313,13 @@ where
 
     fn try_evaluate_obligations(&mut self, infcx: &InferCtxt<'tcx>) -> TraitErrors<E> {
         assert_eq!(self.usable_in_snapshot, infcx.num_open_snapshots());
+        if self.obligations.pending.is_empty() {
+            self.reset_tracking();
+            return TraitErrors::NoErrors;
+        }
+        if self.can_skip_fulfillment(infcx) {
+            return TraitErrors::NoErrors;
+        }
         let mut errors = TraitErrors::NoErrors;
         let delegate = <&SolverDelegate<'tcx>>::from(infcx);
         loop {
@@ -285,6 +412,8 @@ where
             });
             if overflowed {
                 self.obligations.on_fulfillment_overflow(infcx);
+                // Remaining pending goals may be a mix; do not take the skip path.
+                self.all_pending_trackable = false;
                 // Only return true errors that we have accumulated while processing.
                 return errors;
             }
@@ -294,6 +423,8 @@ where
             }
         }
 
+        infcx.reset_min_changed_ty_vid();
+        self.recompute_tracking();
         errors
     }
 
diff --git a/tests/ui/traits/next-solver/fulfillment-skip-unrelated-infer.rs b/tests/ui/traits/next-solver/fulfillment-skip-unrelated-infer.rs
new file mode 100644
index 0000000000000..50387bc8e6327
--- /dev/null
+++ b/tests/ui/traits/next-solver/fulfillment-skip-unrelated-infer.rs
@@ -0,0 +1,35 @@
+//@ check-pass
+//
+// Typeck of a long chain of stalled `Default` obligations, then a
+// constraint that resolves them. Next-solver fulfillment may skip
+// walking the pending queue when only newer, unrelated infer vids
+// changed (rustc#159933). This must still notice the final `u8`.
+
+pub fn big() {
+    let mut v = Vec::new();
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(Default::default());
+    v.push(0u8);
+}
+
+fn main() {
+    big();
+}