AbTcrAI/neodb_page.html at main · XSLiuLab/AbTcrAI · GitHub

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
<!DOCTYPE html>
<html lang="zh-CN">
<head>
    <meta charset="UTF-8">
    <meta name="viewport" content="width=device-width, initial-scale=1.0">
    <title>Neodb - 癌症免疫治疗新抗原数据库与发现平台</title>
    <link rel="stylesheet" href="style.css">
    <style>
        * {
            margin: 0;
            padding: 0;
            box-sizing: border-box;
        }

        body {
            font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, sans-serif;
            line-height: 1.6;
            color: #333;
            overflow-x: hidden;
        }

        /* Hero Section */
        .hero {
            background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
            min-height: 100vh;
            display: flex;
            align-items: center;
            justify-content: center;
            position: relative;
            color: white;
            text-align: center;
        }

        .hero::before {
            content: '';
            position: absolute;
            top: 0;
            left: 0;
            right: 0;
            bottom: 0;
            background: url('data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100"><defs><pattern id="grid" width="10" height="10" patternUnits="userSpaceOnUse"><path d="M 10 0 L 0 0 0 10" fill="none" stroke="rgba(255,255,255,0.1)" stroke-width="0.5"/></pattern></defs><rect width="100" height="100" fill="url(%23grid)"/></svg>');
            opacity: 0.3;
        }

        .hero-content {
            max-width: 800px;
            padding: 0 20px;
            position: relative;
            z-index: 1;
        }

        .hero h1 {
            font-size: 3.5rem;
            font-weight: 700;
            margin-bottom: 1rem;
            animation: fadeInUp 1s ease-out;
        }

        .hero .subtitle {
            font-size: 1.3rem;
            margin-bottom: 2rem;
            opacity: 0.9;
            animation: fadeInUp 1s ease-out 0.3s both;
        }

        .hero .description {
            font-size: 1.1rem;
            margin-bottom: 3rem;
            opacity: 0.8;
            animation: fadeInUp 1s ease-out 0.6s both;
        }

        .cta-buttons {
            display: flex;
            gap: 1rem;
            justify-content: center;
            flex-wrap: wrap;
            animation: fadeInUp 1s ease-out 0.9s both;
        }

        .btn {
            padding: 15px 30px;
            border: none;
            border-radius: 50px;
            font-size: 1.1rem;
            font-weight: 600;
            cursor: pointer;
            transition: all 0.3s ease;
            text-decoration: none;
            display: inline-block;
        }

        .btn-primary {
            background: white;
            color: #667eea;
        }

        .btn-primary:hover {
            transform: translateY(-2px);
            box-shadow: 0 10px 25px rgba(0,0,0,0.2);
        }

        .btn-secondary {
            background: transparent;
            color: white;
            border: 2px solid white;
        }

        .btn-secondary:hover {
            background: white;
            color: #667eea;
            transform: translateY(-2px);
        }

        /* Features Section */
        .features {
            padding: 100px 20px;
            background: #f8fafc;
        }

        .container {
            max-width: 1200px;
            margin: 0 auto;
        }

        .section-title {
            text-align: center;
            font-size: 2.5rem;
            font-weight: 700;
            margin-bottom: 3rem;
            color: #2d3748;
        }

        .features-grid {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
            gap: 3rem;
            margin-top: 4rem;
        }

        .feature-card {
            background: white;
            padding: 2.5rem;
            border-radius: 20px;
            box-shadow: 0 10px 30px rgba(0,0,0,0.1);
            transition: all 0.3s ease;
            text-align: center;
        }

        .feature-card:hover {
            transform: translateY(-10px);
            box-shadow: 0 20px 40px rgba(0,0,0,0.15);
        }

        .feature-icon {
            width: 80px;
            height: 80px;
            margin: 0 auto 1.5rem;
            background: linear-gradient(135deg, #667eea, #764ba2);
            border-radius: 50%;
            display: flex;
            align-items: center;
            justify-content: center;
            font-size: 2rem;
        }

        .feature-card h3 {
            font-size: 1.5rem;
            font-weight: 600;
            margin-bottom: 1rem;
            color: #2d3748;
        }

        .feature-card p {
            color: #718096;
            line-height: 1.7;
        }

        /* Stats Section */
        .stats {
            padding: 80px 20px;
            background: linear-gradient(135deg, #2d3748 0%, #4a5568 100%);
            color: white;
        }

        .stats-grid {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
            gap: 3rem;
            text-align: center;
        }

        .stat-item h3 {
            font-size: 3rem;
            font-weight: 700;
            margin-bottom: 0.5rem;
            color: #90cdf4;
        }

        .stat-item p {
            font-size: 1.1rem;
            opacity: 0.9;
        }

        /* Technology Section */
        .technology {
            padding: 100px 20px;
            background: white;
        }

        .tech-grid {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
            gap: 2rem;
            margin-top: 3rem;
        }

        .tech-item {
            padding: 2rem;
            border: 2px solid #e2e8f0;
            border-radius: 15px;
            transition: all 0.3s ease;
            text-align: center;
        }

        .tech-item:hover {
            border-color: #667eea;
            transform: translateY(-5px);
        }

        .tech-item h4 {
            font-size: 1.3rem;
            font-weight: 600;
            margin-bottom: 1rem;
            color: #2d3748;
        }

        /* Publication Section */
        .publication {
            padding: 80px 20px;
            background: #f7fafc;
        }

        .pub-card {
            background: white;
            padding: 3rem;
            border-radius: 20px;
            box-shadow: 0 10px 30px rgba(0,0,0,0.1);
            text-align: center;
            max-width: 800px;
            margin: 0 auto;
        }

        .pub-card h3 {
            font-size: 1.8rem;
            font-weight: 600;
            margin-bottom: 1rem;
            color: #2d3748;
        }

        .pub-info {
            color: #718096;
            margin-bottom: 2rem;
            font-size: 1.1rem;
        }

        .pub-stats {
            display: flex;
            justify-content: center;
            gap: 2rem;
            margin-top: 2rem;
            flex-wrap: wrap;
        }

        .pub-stat {
            text-align: center;
        }

        .pub-stat strong {
            display: block;
            font-size: 1.5rem;
            color: #667eea;
            font-weight: 700;
        }

        /* Footer */
        .footer {
            background: #2d3748;
            color: white;
            padding: 60px 20px 30px;
            text-align: center;
        }

        .footer-content {
            max-width: 600px;
            margin: 0 auto;
        }

        .footer h3 {
            font-size: 1.5rem;
            margin-bottom: 1rem;
        }

        .footer-links {
            display: flex;
            justify-content: center;
            gap: 2rem;
            margin: 2rem 0;
            flex-wrap: wrap;
        }

        .footer-links a {
            color: #90cdf4;
            text-decoration: none;
            font-weight: 500;
        }

        .footer-links a:hover {
            color: white;
        }

        /* Animations */
        @keyframes fadeInUp {
            from {
                opacity: 0;
                transform: translateY(30px);
            }
            to {
                opacity: 1;
                transform: translateY(0);
            }
        }

        /* Responsive */
        @media (max-width: 768px) {
            .hero h1 {
                font-size: 2.5rem;
            }

            .hero .subtitle {
                font-size: 1.1rem;
            }

            .cta-buttons {
                flex-direction: column;
                align-items: center;
            }

            .section-title {
                font-size: 2rem;
            }

            .features-grid,
            .tech-grid {
                grid-template-columns: 1fr;
            }

            .stats-grid {
                grid-template-columns: repeat(2, 1fr);
            }

            .pub-stats {
                flex-direction: column;
                gap: 1rem;
            }
        }
    </style>
</head>
<body>
    <header>
        <nav class="container">
            <a href="#" class="logo">ImmunoAI</a>
            <ul class="nav-links">
                <li><a href="index.html">首页</a></li>
                <li><a href="index.html#features">核心优势</a></li>
                <li class="dropdown">
                    <a href="#services">数据资源</a>
                    <div class="dropdown-content">
                        <a href="tsmpdb.html">肿瘤膜蛋白数据库</a>
                        <a href="neodb_page.html">肿瘤新抗原数据库</a>
                    </div>
                </li>
                <li class="dropdown">
                    <a href="#tools">AI设计工具</a>
                    <div class="dropdown-content">
                        <a href="antibody_design.html">抗体设计</a>
                        <a href="tcr_design.html">TCR设计</a>
                        <a href="tcr_design.html">定向进化</a>
                    </div>
                </li>
                <li><a href="contact_page.html">联系我们</a></li>
            </ul>
        </nav>
    </header>
    <!-- Hero Section -->
    <section class="hero">
        <div class="hero-content">
            <h1>Neodb</h1>
            <p class="subtitle">癌症免疫治疗新抗原数据库与发现平台</p>
            <p class="description">
                全球最大的实验验证新抗原数据库，集成先进的图神经网络预测模型，为癌症免疫治疗提供全面的新抗原发现解决方案
            </p>
            <div class="cta-buttons">
                <a href="https://liuxslab.com/Neodb/" class="btn btn-primary">立即使用平台</a>
                <button id="learn-more-btn" class="btn btn-secondary" onclick="window.location.href = 'https://doi.org/10.1093/database/baad041';" >了解更多</button>
            </div>
        </div>
    </section>

    <!-- Features Section -->
    <section class="features" id="features">
        <div class="container">
            <h2 class="section-title">四大核心模块</h2>
            <div class="features-grid">
                <div class="feature-card">
                    <div class="feature-icon">🧪</div>
                    <h3>Val-Neo 验证模块</h3>
                    <p>收录1,463个实验验证的免疫原性新抗原肽段，来源于206篇研究论文，是目前最全面的验证新抗原数据库</p>
                </div>
                <div class="feature-card">
                    <div class="feature-icon">🧬</div>
                    <h3>Driver-Neo 驱动模块</h3>
                    <p>基于451个基因的3,068个复发性驱动突变，通过多特征筛选提供20,971个候选新抗原列表</p>
                </div>
                <div class="feature-card">
                    <div class="feature-icon">🛠️</div>
                    <h3>Tools 工具模块</h3>
                    <p>集成业界领先的新抗原预测工具，包括抗原处理、抗原结合和免疫原性预测三大类别</p>
                </div>
                <div class="feature-card">
                    <div class="feature-icon">🤖</div>
                    <h3>Immuno-GNN 模型</h3>
                    <p>基于图神经网络的创新免疫原性预测模型，首次将GNN技术应用于新抗原免疫原性预测</p>
                </div>
            </div>
        </div>
    </section>

    <!-- Stats Section -->
    <section class="stats">
        <div class="container">
            <h2 class="section-title">数据规模</h2>
            <div class="stats-grid">
                <div class="stat-item">
                    <h3>1,463</h3>
                    <p>实验验证新抗原</p>
                </div>
                <div class="stat-item">
                    <h3>20,971</h3>
                    <p>候选新抗原</p>
                </div>
                <div class="stat-item">
                    <h3>206</h3>
                    <p>研究论文</p>
                </div>
                <div class="stat-item">
                    <h3>451</h3>
                    <p>癌症驱动基因</p>
                </div>
            </div>
        </div>
    </section>

    <!-- Technology Section -->
    <section class="technology">
        <div class="container">
            <h2 class="section-title">技术优势</h2>
            <div class="tech-grid">
                <div class="tech-item">
                    <h4>图神经网络</h4>
                    <p>首次将GNN应用于新抗原免疫原性预测，考虑HLA与抗原肽段的空间相互作用</p>
                </div>
                <div class="tech-item">
                    <h4>注意力机制</h4>
                    <p>采用注意力机制捕捉不同氨基酸之间的复杂相互作用关系</p>
                </div>
                <div class="tech-item">
                    <h4>多特征整合</h4>
                    <p>整合蛋白酶体切割、TAP转运效率、肽段-HLA结合稳定性等多维特征</p>
                </div>
                <div class="tech-item">
                    <h4>批量处理</h4>
                    <p>支持MAF、VCF、TXT等多种文件格式的批量输入和处理</p>
                </div>
            </div>
        </div>
    </section>

    <!-- Publication Section -->
    <section class="publication">
        <div class="container">
            <h2 class="section-title">学术发表</h2>
            <div class="pub-card">
                <h3>Neodb: a comprehensive neoantigen database and discovery platform for cancer immunotherapy</h3>
                <p class="pub-info">
                    发表于 <strong>Database</strong> 期刊 (Volume 2023) <br>
                    DOI: <a href="https://doi.org/10.1093/database/baad041" style="color: #667eea;">10.1093/database/baad041</a>
                </p>
                <div class="pub-stats">
                    <div class="pub-stat">
                        <strong>Open Access</strong>
                        <span>开放获取</span>
                    </div>
                    <div class="pub-stat">
                        <strong>2023年6月</strong>
                        <span>发表时间</span>
                    </div>

                </div>
            </div>
        </div>
    </section>

    <!-- Footer -->
    <footer class="footer">
        <div class="footer-content">
            <h3>开始您的新抗原发现之旅</h3>
            <p>Neodb致力于推动癌症免疫治疗的发展，为研究人员提供最全面的新抗原发现平台</p>
            <div class="footer-links">
                <a href="https://liuxslab.com/Neodb/">访问平台</a>
                <a href="https://doi.org/10.1093/database/baad041">阅读论文</a>
                <a href="contact_page.html">联系我们</a>
            </div>
            <p style="margin-top: 2rem; opacity: 0.7;">© 2025 Neodb Team. All rights reserved.</p>
        </div>
    </footer>

    <script>
        // Smooth scrolling for anchor links
        document.querySelectorAll('a[href^="#"]').forEach(anchor => {
            anchor.addEventListener('click', function (e) {
                e.preventDefault();
                document.querySelector(this.getAttribute('href')).scrollIntoView({
                    behavior: 'smooth'
                });
            });
        });

        // Handle "了解更多" button click to switch Shiny tab
        document.getElementById('learn-more-btn').addEventListener('click', function() {
            // Send message to Shiny to switch to contact tab
            if (window.Shiny) {
                Shiny.setInputValue('switch_to_contact', Math.random(), {priority: 'event'});
            }
        });

        // Add scroll animations
        const observerOptions = {
            threshold: 0.1,
            rootMargin: '0px 0px -50px 0px'
        };

        const observer = new IntersectionObserver((entries) => {
            entries.forEach(entry => {
                if (entry.isIntersecting) {
                    entry.target.style.opacity = '1';
                    entry.target.style.transform = 'translateY(0)';
                }
            });
        }, observerOptions);

        // Observe elements for animation
        document.querySelectorAll('.feature-card, .tech-item, .stat-item').forEach(el => {
            el.style.opacity = '0';
            el.style.transform = 'translateY(20px)';
            el.style.transition = 'opacity 0.6s ease, transform 0.6s ease';
            observer.observe(el);
        });
    </script>
</body>
</html>