diff --git a/packages/main/cypress/specs/List.cy.tsx b/packages/main/cypress/specs/List.cy.tsx
index 2afa8145fc19..42a3372fbc8d 100644
--- a/packages/main/cypress/specs/List.cy.tsx
+++ b/packages/main/cypress/specs/List.cy.tsx
@@ -598,6 +598,27 @@ describe("List - Accessibility", () => {
 			});
 	});
 
+	it("does not announce F2 instruction for custom list items without tabbable content", () => {
+		cy.mount(
+			<List selectionMode="None">
+				<ListItemCustom>Pineapple</ListItemCustom>
+				<ListItemCustom>Papaya</ListItemCustom>
+			</List>
+		);
+
+		cy.get("[ui5-list]")
+			.shadow()
+			.find(".ui5-list-ul")
+			.invoke("attr", "aria-description")
+			.then((ariaDesc) => {
+				cy.get("[ui5-list]")
+					.should(($list) => {
+						const defaultText = $list.prop("defaultAriaDescriptionText") as string;
+						expect(ariaDesc ?? "").to.not.include(defaultText);
+					});
+			});
+	});
+
 	it("announces 'Selected' when an item is selected in Single mode via mouse click", () => {
 		cy.mount(
 			<List selectionMode="Single">
diff --git a/packages/main/src/List.ts b/packages/main/src/List.ts
index 8dd1180aece4..db0570d2c79d 100644
--- a/packages/main/src/List.ts
+++ b/packages/main/src/List.ts
@@ -780,7 +780,13 @@ class List extends UI5Element {
 		}
 
 		return this.getItems().some(item => {
-			return item.getAttribute("type") === "Detail" || isInstanceOfListItemCustom(item);
+			if (item.getAttribute("type") === "Detail") {
+				return true;
+			}
+			if (isInstanceOfListItemCustom(item)) {
+				return item._hasFocusableElements();
+			}
+			return false;
 		});
 	}