diff --git a/packages/main/cypress/specs/Dialog.cy.tsx b/packages/main/cypress/specs/Dialog.cy.tsx
index 686ad9cef953..a9ded9140d87 100644
--- a/packages/main/cypress/specs/Dialog.cy.tsx
+++ b/packages/main/cypress/specs/Dialog.cy.tsx
@@ -1244,6 +1244,59 @@ describe("Acc", () => {
 			.and("have.attr", "aria-modal", "true");
 	});
 
+	it("tests header, content and footer regions", () => {
+		cy.mount(
+			<Dialog id="dialog-regions" headerText="Region Test">
+				<div>Some content</div>
+				<Button slot="footer">OK</Button>
+			</Dialog>
+		);
+
+		cy.get("#dialog-regions")
+			.invoke("prop", "open", true);
+
+		cy.get<Dialog>("#dialog-regions").ui5DialogOpened();
+
+		// Header region
+		cy.get("#dialog-regions")
+			.shadow()
+			.find(".ui5-popup-header-root")
+			.should("have.attr", "role", "region")
+			.and("have.attr", "aria-label", "Header");
+
+		// Content region
+		cy.get("#dialog-regions")
+			.shadow()
+			.find(".ui5-popup-content")
+			.should("have.attr", "role", "region")
+			.and("have.attr", "aria-label", "Content");
+
+		// Footer region
+		cy.get("#dialog-regions")
+			.shadow()
+			.find(".ui5-popup-footer-root")
+			.should("have.attr", "role", "region")
+			.and("have.attr", "aria-label", "Footer");
+	});
+
+	it("tests footer region is not rendered when no footer slot is provided", () => {
+		cy.mount(
+			<Dialog id="dialog-no-footer" headerText="No Footer">
+				<div>Some content</div>
+			</Dialog>
+		);
+
+		cy.get("#dialog-no-footer")
+			.invoke("prop", "open", true);
+
+		cy.get<Dialog>("#dialog-no-footer").ui5DialogOpened();
+
+		cy.get("#dialog-no-footer")
+			.shadow()
+			.find(".ui5-popup-footer-root")
+			.should("not.exist");
+	});
+
 });
 
 describe("Page scrolling", () => {
diff --git a/packages/main/src/Dialog.ts b/packages/main/src/Dialog.ts
index 89bd2b46ca4b..9596e0562044 100644
--- a/packages/main/src/Dialog.ts
+++ b/packages/main/src/Dialog.ts
@@ -22,6 +22,9 @@ import {
 	DIALOG_HEADER_ARIA_DESCRIBEDBY_RESIZABLE,
 	DIALOG_HEADER_ARIA_DESCRIBEDBY_DRAGGABLE,
 	DIALOG_HEADER_ARIA_DESCRIBEDBY_DRAGGABLE_RESIZABLE,
+	DIALOG_HEADER_ARIA_LABEL,
+	DIALOG_CONTENT_ARIA_LABEL,
+	DIALOG_FOOTER_ARIA_LABEL,
 } from "./generated/i18n/i18n-defaults.js";
 
 // Template
@@ -327,6 +330,22 @@ class Dialog extends Popup {
 		return toLowercaseEnumValue(this.accessibleRole);
 	}
 
+	get _contentRole(): "region" {
+		return "region";
+	}
+
+	get _headerAriaLabel() {
+		return Dialog.i18nBundle.getText(DIALOG_HEADER_ARIA_LABEL);
+	}
+
+	get _contentAriaLabel() {
+		return Dialog.i18nBundle.getText(DIALOG_CONTENT_ARIA_LABEL);
+	}
+
+	get _footerAriaLabel() {
+		return Dialog.i18nBundle.getText(DIALOG_FOOTER_ARIA_LABEL);
+	}
+
 	_show() {
 		super._show();
 		this._center();
diff --git a/packages/main/src/DialogTemplate.tsx b/packages/main/src/DialogTemplate.tsx
index 31bdd6f54300..3575a770d021 100644
--- a/packages/main/src/DialogTemplate.tsx
+++ b/packages/main/src/DialogTemplate.tsx
@@ -14,39 +14,38 @@ export default function DialogTemplate(this: Dialog) {
 function beforeContent(this: Dialog) {
 	return (<>
 		{!!this._displayHeader &&
-			<header>
-				<div
-					class="ui5-popup-header-root"
-					id="ui5-popup-header"
-					role="group"
-					aria-describedby={this.effectiveAriaDescribedBy}
-					aria-roledescription={this.ariaRoleDescriptionHeaderText}
-					tabIndex={this._headerTabIndex}
-					onKeyDown={this._onDragOrResizeKeyDown}
-					onMouseDown={this._onDragMouseDown}
-					part="header"
-					// state={this.state}
-				>
-					{this.hasValueState &&
-						<Icon class="ui5-dialog-value-state-icon" name={this._dialogStateIcon}></Icon>
-					}
-					{this.header.length ?
-						<slot name="header"></slot>
-						:
-						<Title level="H1" id="ui5-popup-header-text" class="ui5-popup-header-text">{this.headerText}</Title>
-					}
+			<div
+				class="ui5-popup-header-root"
+				id="ui5-popup-header"
+				role="region"
+				aria-label={this._headerAriaLabel}
+				aria-describedby={this.effectiveAriaDescribedBy}
+				aria-roledescription={this.ariaRoleDescriptionHeaderText}
+				tabIndex={this._headerTabIndex}
+				onKeyDown={this._onDragOrResizeKeyDown}
+				onMouseDown={this._onDragMouseDown}
+				part="header"
+				// state={this.state}
+			>
+				{this.hasValueState &&
+					<Icon class="ui5-dialog-value-state-icon" name={this._dialogStateIcon}></Icon>
+				}
+				{this.header.length ?
+					<slot name="header"></slot>
+					:
+					<Title level="H1" id="ui5-popup-header-text" class="ui5-popup-header-text">{this.headerText}</Title>
+				}
 
-					{this.resizable ?
-						this.draggable ?
-							<span id={`${this._id}-descr`} aria-hidden="true" class="ui5-hidden-text">{this.ariaDescribedByHeaderTextDraggableAndResizable}</span>
-							:
-							<span id={`${this._id}-descr`} aria-hidden="true" class="ui5-hidden-text">{this.ariaDescribedByHeaderTextResizable}</span>
+				{this.resizable ?
+					this.draggable ?
+						<span id={`${this._id}-descr`} aria-hidden="true" class="ui5-hidden-text">{this.ariaDescribedByHeaderTextDraggableAndResizable}</span>
 						:
-						this.draggable &&
-							<span id={`${this._id}-descr`} aria-hidden="true" class="ui5-hidden-text">{this.ariaDescribedByHeaderTextDraggable}</span>
-					}
-				</div>
-			</header>
+						<span id={`${this._id}-descr`} aria-hidden="true" class="ui5-hidden-text">{this.ariaDescribedByHeaderTextResizable}</span>
+					:
+					this.draggable &&
+						<span id={`${this._id}-descr`} aria-hidden="true" class="ui5-hidden-text">{this.ariaDescribedByHeaderTextDraggable}</span>
+				}
+			</div>
 		}
 	</>);
 }
@@ -54,9 +53,14 @@ function beforeContent(this: Dialog) {
 function afterContent(this: Dialog) {
 	return (<>
 		{!!this.footer.length &&
-			<footer class="ui5-popup-footer-root" part="footer">
+			<div
+				class="ui5-popup-footer-root"
+				role="region"
+				aria-label={this._footerAriaLabel}
+				part="footer"
+			>
 				<slot name="footer"></slot>
-			</footer>
+			</div>
 		}
 		{this._showResizeHandle &&
 			<div
diff --git a/packages/main/src/Popup.ts b/packages/main/src/Popup.ts
index 86265a57a776..aea30042a49f 100644
--- a/packages/main/src/Popup.ts
+++ b/packages/main/src/Popup.ts
@@ -3,7 +3,7 @@ import { renderFinished } from "@ui5/webcomponents-base/dist/Render.js";
 import event from "@ui5/webcomponents-base/dist/decorators/event-strict.js";
 import slot from "@ui5/webcomponents-base/dist/decorators/slot-strict.js";
 import property from "@ui5/webcomponents-base/dist/decorators/property.js";
-import type { ClassMap } from "@ui5/webcomponents-base/dist/types.js";
+import type { ClassMap, AriaRole } from "@ui5/webcomponents-base/dist/types.js";
 import jsxRender from "@ui5/webcomponents-base/dist/renderer/JsxRenderer.js";
 import UI5Element from "@ui5/webcomponents-base/dist/UI5Element.js";
 import type { DefaultSlot } from "@ui5/webcomponents-base/dist/UI5Element.js";
@@ -706,6 +706,14 @@ abstract class Popup extends UI5Element {
 		return (this.accessibleRole === PopupAccessibleRole.None) ? undefined : toLowercaseEnumValue(this.accessibleRole);
 	}
 
+	get _contentRole(): AriaRole | undefined {
+		return undefined;
+	}
+
+	get _contentAriaLabel(): string | undefined {
+		return undefined;
+	}
+
 	get _ariaModal(): "true" | undefined {
 		return this.accessibleRole === PopupAccessibleRole.None ? undefined : "true";
 	}
diff --git a/packages/main/src/PopupTemplate.tsx b/packages/main/src/PopupTemplate.tsx
index 3883b1fdc123..eb455e244a09 100644
--- a/packages/main/src/PopupTemplate.tsx
+++ b/packages/main/src/PopupTemplate.tsx
@@ -27,7 +27,14 @@ export default function PopupTemplate(this: Popup, hooks?: {
 
 			{(hooks?.beforeContent || beforeContent).call(this)}
 
-			<div style={this.styles.content} class={this.classes.content} onScroll={this._scroll} part="content">
+			<div
+				style={this.styles.content}
+				class={this.classes.content}
+				role={this._contentRole}
+				aria-label={this._contentAriaLabel}
+				onScroll={this._scroll}
+				part="content"
+			>
 				<slot></slot>
 			</div>
 
diff --git a/packages/main/src/i18n/messagebundle.properties b/packages/main/src/i18n/messagebundle.properties
index b43e02c4c878..6e44a54d20c8 100644
--- a/packages/main/src/i18n/messagebundle.properties
+++ b/packages/main/src/i18n/messagebundle.properties
@@ -840,6 +840,15 @@ DIALOG_HEADER_ARIA_DESCRIBEDBY_DRAGGABLE=Use Arrow keys to move
 
 #XACT: ARIA announcement for describedby attribute of draggable and resizable Dialog header
 DIALOG_HEADER_ARIA_DESCRIBEDBY_DRAGGABLE_RESIZABLE=Use Arrow keys to move, Shift+Arrow keys to resize
+
+#XACT: ARIA label for the Dialog header region
+DIALOG_HEADER_ARIA_LABEL=Header
+
+#XACT: ARIA label for the Dialog content region
+DIALOG_CONTENT_ARIA_LABEL=Content
+
+#XACT: ARIA label for the Dialog footer region
+DIALOG_FOOTER_ARIA_LABEL=Footer
 #XFLD: A colon to separate the "label" from an input. In some languages there might be a different symbol used for such a colon
 LABEL_COLON=: