[OEC] OpenVent is not Deep Vent

[jcmolloy]

Describe the Problem

OpenVent is this protein which is a Pyrococcus sp. GE 23 (which is a strain of deep sea vent archaea Pyrococcus abyssi or a close relative) and NOT Pyrococcus sp. GB-D which is the source of OpenVent and the Deep Vent sequence in UniProt.

Sequence Data

US_6673585_B1_2 - current OpenVent
MIIDADYITE DGKPIIRIFK KEKGEFKVEY DRTFRPYIYA LLKDDSAIDE
VKKITAERHG KIVRITEVEK VQKKFLGRPI EVWKLYLEHP QDVPAIREKI
REHPAVVDIF EYDIPFAKRY LIDKGLTPME GNEELTFLAV DIETLYHEGE
EFGKGPIIMI SYADEEGAKV ITWKSIDLPY VEVVSSEREM IKRLVKVIRE
KDPDVIITYN GDNFDFPYLL KRAEKLGIKL PLGRDNSEPK MQRMGDSLAV
EIKGRIHFDL FPVIRRTINL PTYTLEAVYE AIFGKSKEKV YAHEIAEAWE
TGKGLERVAK YSMEDAKVTF ELGKEFFPME AQLARLVGQP VWDVSRSSTG
NLVEWFLLRK AYERNELAPN KPDEREYERR LRESYEGGYV KEPEKGLWEG
IVSLDFRSLY PSIIITHNVS PDTLNRENCK EYDVAPQVGH RFCKDFPGFI
PSLLGNLLEE RQKIKKRMKE SKDPVEKKLL DYRQRAIKIL ANSYYGYYGY
AKARWYCKEC AESVTAWGRQ YIDLVRRELE SSGFKVLYID TDGLYATIPG
AKPNEIKEKA LKFVEYINSK LPGLLELEYE GFYARGFFVT KKKYALIDEE
GKIVTRGLEI VRRDWSEIAK ETQAKVLEAI LKHGNVDEAV KIVKEVTEKL
SKYEIPPEKL VIYEQITRPL SEYKAIGPHV AVAKRLAAKG VKVKPGMVIG
YIVLRGDGPI SKRAIAIEEF DPKKHKYDAE YYIENQVLPA VERILRAFGY
RKEDLRYQKT KQVGLGAWLK F

sp|Q51334|DPOL_PYRSD DNA polymerase OS=Pyrococcus sp. (strain GB-D) OX=69013 GN=pol PE=1 SV=1
MILDADYITEDGKPIIRIFKKENGEFKVEYDRNFRPYIYALLKDDSQIDEVRKITAERHG
KIVRIIDAEKVRKKFLGRPIEVWRLYFEHPQDVPAIRDKIREHSAVIDIFEYDIPFAKRY
LIDKGLIPMEGDEELKLLAFDIETLYHEGEEFAKGPIIMISYADEEEAKVITWKKIDLPY
VEVVSSEREMIKRFLKVIREKDPDVIITYNGDSFDLPYLVKRAEKLGIKLPLGRDGSEPK
MQRLGDMTAVEIKGRIHFDLYHVIRRTINLPTYTLEAVYEAIFGKPKEKVYAHEIAEAWE
TGKGLERVAKYSMEDAKVTYELGREFFPMEAQLSRLVGQPLWDVSRSSTGNLVEWYLLRK
AYERNELAPNKPDEREYERRLRESYAGGYVKEPEKGLWEGLVSLDFRSLYPSIIITHNVS
PDTLNREGCREYDVAPEVGHKFCKDFPGFIPSLLKRLLDERQEIKRKMKASKDPIEKKML
DYRQRAIKILANSILPEEWVPLIKNGKVKIFRIGDFVDGLMKANQGKVKKTGDTEVLEVA
GIHAFSFDRKSKKARVMAVKAVIRHRYSGNVYRIVLNSGRKITITEGHSLFVYRNGDLVE
ATGEDVKIGDLLAVPRSVNLPEKRERLNIVELLLNLSPEETEDIILTIPVKGRKNFFKGM
LRTLRWIFGEEKRVRTASRYLRHLENLGYIRLRKIGYDIIDKEGLEKYRTLYEKLVDVVR
YNGNKREYLVEFNAVRDVISLMPEEELKEWRIGTRNGFRMGTFVDIDEDFAKLLGYYVSE
GSARKWKNQTGGWSYTVRLYNENDEVLDDMEHLAKKFFGKVKRGKNYVEIPKKMAYIIFE
SLCGTLAENKRVPEVIFTSSKGVRWAFLEGYFIGDGDVHPSKRVRLSTKSELLVNGLVLL
LNSLGVSAIKLGYDSGVYRVYVNEELKFTEYRKKKNVYHSHIVPKDILKETFGKVFQKNI
SYKKFRELVENGKLDREKAKRIEWLLNGDIVLDRVVEIKREYYDGYVYDLSVDEDENFLA
GFGFLYAHNSYYGYYGYAKARWYCKECAESVTAWGREYIEFVRKELEEKFGFKVLYIDTD
GLYATIPGAKPEEIKKKALEFVDYINAKLPGLLELEYEGFYVRGFFVTKKKYALIDEEGK
IITRGLEIVRRDWSEIAKETQAKVLEAILKHGNVEEAVKIVKEVTEKLSKYEIPPEKLVI
YEQITRPLHEYKAIGPHVAVAKRLAARGVKVRPGMVIGYIVLRGDGPISKRAILAEEFDL
RKHKYDAEYYIENQVLPAVLRILEAFGYRKEDLRWQKTKQTGLTAWLNIKKK

**Follow-Up Actions **

• Synthesise Deep Vent
• Update OpenVent description to be clear that it is not the same as Deep Vent (but does come from a similar organism from a thermal vent.