diff --git a/.github/workflows/dev-build.yml b/.github/workflows/dev-build.yml
index b60e876..95b49c8 100644
--- a/.github/workflows/dev-build.yml
+++ b/.github/workflows/dev-build.yml
@@ -37,6 +37,10 @@ jobs:
       - name: Check out the repo
         uses: actions/checkout@v4
 
+      # Enable multi-architecture builds via QEMU emulation
+      - name: Set up QEMU
+        uses: docker/setup-qemu-action@v3
+
       # Enable advanced Docker build features (required for caching)
       - name: Set up Docker Buildx
         uses: docker/setup-buildx-action@v3
@@ -64,6 +68,7 @@ jobs:
           context: .
           file: ./Dockerfile
           push: true
+          platforms: linux/amd64,linux/arm64
           build-args: RELEASE_VERSION=${{ env.RELEASE_TAG }}
           tags: ${{ env.REPOSITORY_NAMESPACE }}/${{ env.NMRKIT_REPOSITORY_NAME }}:${{ env.RELEASE_TAG }}
           cache-from: type=registry,ref=${{ env.REPOSITORY_NAMESPACE }}/${{ env.NMRKIT_REPOSITORY_NAME }}:buildcache
diff --git a/.github/workflows/prod-build.yml b/.github/workflows/prod-build.yml
index 62fb832..aaa1b62 100644
--- a/.github/workflows/prod-build.yml
+++ b/.github/workflows/prod-build.yml
@@ -73,6 +73,10 @@ jobs:
       - name: Check out the repo
         uses: actions/checkout@v4
 
+      # Enable multi-architecture builds via QEMU emulation
+      - name: Set up QEMU
+        uses: docker/setup-qemu-action@v3
+
       # Enable advanced Docker build features (required for caching)
       - name: Set up Docker Buildx
         uses: docker/setup-buildx-action@v3
@@ -100,6 +104,7 @@ jobs:
           context: .
           file: ./Dockerfile
           push: true
+          platforms: linux/amd64,linux/arm64
           build-args: RELEASE_VERSION=${{ env.RELEASE_TAG }}
           tags: ${{ env.REPOSITORY_NAMESPACE }}/${{ env.NMRKIT_REPOSITORY_NAME }}:${{ env.RELEASE_TAG }}
           cache-from: type=registry,ref=${{ env.REPOSITORY_NAMESPACE }}/${{ env.NMRKIT_REPOSITORY_NAME }}:buildcache
diff --git a/Dockerfile b/Dockerfile
index 79f3b16..8d747a5 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -1,4 +1,5 @@
 FROM continuumio/miniconda3:24.1.2-0 AS nmrkit-ms
+ARG TARGETARCH
 
 ENV PYTHON_VERSION=3.10
 ENV OPENBABEL_VERSION=v3.1
@@ -30,7 +31,7 @@ RUN pip3 install rdkit
 
 RUN python3 -m pip install -U pip
 
-ENV JAVA_HOME=/usr/lib/jvm/java-17-openjdk-amd64/
+ENV JAVA_HOME=/usr/lib/jvm/java-17-openjdk-${TARGETARCH}/
 RUN export JAVA_HOME
 
 RUN git clone "https://github.com/rinikerlab/lightweight-registration.git" lwreg