diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 236b65e..fcd3054 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -52,7 +52,7 @@ jobs:
   flatpak-build-test:
     runs-on: ubuntu-24.04
     container:
-      image: ghcr.io/flathub-infra/flatpak-github-actions:gnome-48
+      image: ghcr.io/flathub-infra/flatpak-github-actions:gnome-49
       options: --privileged
     steps:
     - uses: actions/checkout@v6
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 5221c16..a33e0b5 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,6 +10,9 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ### Changed
 
 - Update release process documentation (@MightyCreak)
+- Minimal Pytnon release is now 3.10 (@MightyCreak)
+- Update flatpak's GNOME runtime to 49 (@MightyCreak)
+- Update PyPi requirements (@MightyCreak)
 
 ### Fixed
 
diff --git a/docs/developers/developers-setup.md b/docs/developers/developers-setup.md
index bf8afc1..b01c388 100644
--- a/docs/developers/developers-setup.md
+++ b/docs/developers/developers-setup.md
@@ -4,7 +4,7 @@
 
 Diffuse depends on these projects:
 
-* Python 3.8+
+* Python 3.10+
 * PyPi
 * Cairo and GObject Introspection development headers
 * Meson
@@ -81,7 +81,7 @@ git config --local core.hooksPath ./.githooks
 To build, test and install Diffuse locally:
 
 ```sh
-flatpak install runtime/org.gnome.Sdk/$(uname -m)/48
+flatpak install runtime/org.gnome.Sdk/$(uname -m)/49
 flatpak-builder --user --install build-flatpak io.github.mightycreak.Diffuse.yml
 ```
 
diff --git a/io.github.mightycreak.Diffuse.yml b/io.github.mightycreak.Diffuse.yml
index c2aa7b3..1a828ab 100644
--- a/io.github.mightycreak.Diffuse.yml
+++ b/io.github.mightycreak.Diffuse.yml
@@ -1,6 +1,6 @@
 app-id: io.github.mightycreak.Diffuse
 runtime: org.gnome.Platform
-runtime-version: '48'
+runtime-version: '49'
 sdk: org.gnome.Sdk
 command: diffuse
 finish-args:
diff --git a/requirements.dev.txt b/requirements.dev.txt
index 36c9add..ad4aa5c 100644
--- a/requirements.dev.txt
+++ b/requirements.dev.txt
@@ -1,4 +1,4 @@
 -r requirements.txt
-flake8 ~= 7.0
+flake8 ~= 7.2
 flake8-noqa ~= 1.4
-mypy ~= 1.11
+mypy ~= 1.16
diff --git a/requirements.txt b/requirements.txt
index c7edac4..7d2c2fd 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1 +1 @@
-PyGObject ~= 3.48
+PyGObject ~= 3.54