diff --git a/azure-pipelines.yml b/azure-pipelines.yml
index 659eeff70d..053b2a2ef8 100644
--- a/azure-pipelines.yml
+++ b/azure-pipelines.yml
@@ -1,5 +1,5 @@
 trigger:
-  # start a new build for every push
+  # start a new build for every push (triggering run 2 for cache verification)
   batch: False
   branches:
     include:
@@ -19,6 +19,7 @@ jobs:
   condition: and(succeeded(), ne(variables['Build.SourceBranch'], 'refs/heads/develop'))  # skip for PR merges
   variables:
     MPLBACKEND: agg
+    CACHE_VERSION: '1'
   strategy:
     matrix:
         Win-Python311-64bit-full:
@@ -63,6 +64,29 @@ jobs:
       versionSpec: $(PYTHON_VERSION)
       addToPath: true
       architecture: $(PYTHON_ARCH)
+
+  - powershell: |
+      $cachePath = Join-Path $env:LOCALAPPDATA "pip\Cache"
+      if (!(Test-Path $cachePath)) { New-Item -ItemType Directory -Force -Path $cachePath }
+      Write-Host "##vso[task.setvariable variable=PIP_CACHE_DIR]$cachePath"
+    displayName: 'Set pip cache directory (Windows)'
+    condition: eq(variables['Agent.OS'], 'Windows_NT')
+
+  - bash: |
+      CACHE_DIR="$HOME/.cache/pip"
+      mkdir -p "$CACHE_DIR"
+      echo "##vso[task.setvariable variable=PIP_CACHE_DIR]$CACHE_DIR"
+    displayName: 'Set pip cache directory (Linux)'
+    condition: eq(variables['Agent.OS'], 'Linux')
+
+  - task: Cache@2
+    inputs:
+      key: 'pip | "$(Agent.OS)" | "$(PYTHON_VERSION)" | "$(BUILD_TYPE)" | "$(imageName)" | "$(CACHE_VERSION)" | package/requirements.txt'
+      restoreKeys: |
+        pip | "$(Agent.OS)" | "$(PYTHON_VERSION)" | "$(BUILD_TYPE)" | "$(imageName)" | "$(CACHE_VERSION)"
+        pip | "$(Agent.OS)" | "$(PYTHON_VERSION)" | "$(BUILD_TYPE)" | "$(imageName)"
+      path: $(PIP_CACHE_DIR)
+    displayName: 'Cache pip'
   # a PEP518 compliant wheel build shoud be
   # able to build MDAnalysis in an isolated
   # environment *before* any deps are installed
diff --git a/package/AUTHORS b/package/AUTHORS
index a799200bf5..729dbd7676 100644
--- a/package/AUTHORS
+++ b/package/AUTHORS
@@ -275,6 +275,7 @@ Chronological list of authors
   - Harshit Gajjela
   - Kunj Sinha
   - Ayush Agarwal
+  - Unnati Kadam
 
 External code
 -------------
diff --git a/package/CHANGELOG b/package/CHANGELOG
index 790bbbe80f..bc75941537 100644
--- a/package/CHANGELOG
+++ b/package/CHANGELOG
@@ -50,6 +50,7 @@ Enhancements
  * Adds support for parsing `.tpr` files produced by GROMACS 2026.0
  * Enables parallelization for analysis.diffusionmap.DistanceMatrix
    (Issue #4679, PR #4745)
+ * Implement pip dependency caching for Azure Pipelines (PR #5267)
 
 Changes
  * The msd.py inside analysis is changed, and ProgressBar is implemented inside