diff --git a/dockstore-webservice/src/main/resources/requirements/1.6.0/requirements.txt b/dockstore-webservice/src/main/resources/requirements/1.6.0/requirements.txt
index 29b1e9d740..8d75f39037 100644
--- a/dockstore-webservice/src/main/resources/requirements/1.6.0/requirements.txt
+++ b/dockstore-webservice/src/main/resources/requirements/1.6.0/requirements.txt
@@ -1,4 +1,4 @@
-setuptools==40.8.0
+setuptools==65.5.1
 cwl-runner
 cwltool==1.0.20181217162649
 schema-salad==3.0.20181206233650
diff --git a/dockstore-webservice/src/main/resources/requirements/1.6.0/requirements3.txt b/dockstore-webservice/src/main/resources/requirements/1.6.0/requirements3.txt
index 5f339552f3..fae88cb222 100644
--- a/dockstore-webservice/src/main/resources/requirements/1.6.0/requirements3.txt
+++ b/dockstore-webservice/src/main/resources/requirements/1.6.0/requirements3.txt
@@ -1,4 +1,4 @@
-setuptools==40.8.0
+setuptools==65.5.1
 cwl-runner
 cwltool==1.0.20181217162649
 schema-salad==3.0.20181206233650