diff --git a/Modules/ThirdParty/MINC/src/CMakeLists.txt b/Modules/ThirdParty/MINC/src/CMakeLists.txt
index 0646036a656..3ba583dc03f 100644
--- a/Modules/ThirdParty/MINC/src/CMakeLists.txt
+++ b/Modules/ThirdParty/MINC/src/CMakeLists.txt
@@ -35,15 +35,7 @@ set(LIBRARY_OUTPUT_PATH ${CMAKE_LIBRARY_OUTPUT_DIRECTORY})
 set(ZLIB_FOUND ON)
 set(HDF5_FOUND ON)
 
-if(NOT ITK_USE_SYSTEM_HDF5)
-  set(HDF5_INCLUDE_DIRS ${ITKHDF5_SOURCE_DIR}/src/itkhdf5)
-  include_directories(
-    "${ITKHDF5_SOURCE_DIR}/src/itkhdf5"
-    "${ITKHDF5_SOURCE_DIR}/src/itkhdf5/src"
-    "${ITKHDF5_BINARY_DIR}/src/itkhdf5"
-  )
-endif()
-set(HDF5_LIBRARIES ${ITKHDF5_LIBRARIES})
+set(HDF5_LIBRARIES ITK::ITKHDF5Module)
 
 set(BUILD_TESTING OFF)
 add_subdirectory(libminc)
diff --git a/Modules/ThirdParty/MINC/src/libminc/libcommon/ParseArgv.c b/Modules/ThirdParty/MINC/src/libminc/libcommon/ParseArgv.c
index 6589c5498ff..12d50c2b85f 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libcommon/ParseArgv.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libcommon/ParseArgv.c
@@ -38,7 +38,7 @@
 #endif
 
 #ifdef HAVE_MINC2
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #endif
 
 #include <math.h>
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc/minc.h b/Modules/ThirdParty/MINC/src/libminc/libsrc/minc.h
index 7eec6448d02..6b6d84e0bb6 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc/minc.h
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc/minc.h
@@ -167,7 +167,7 @@
 #endif /* MNCAPI not defined */
 
 #if MINC2
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include <netcdf.h>
 #include "minc_compat.h"
 #else
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/convert.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/convert.c
index 6812aced8d3..1f2c4bde6fe 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/convert.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/convert.c
@@ -10,7 +10,7 @@
  * \defgroup mi2Cvt MINC 2.0 Coordinate and Voxel Conversion Functions
  */
 #include <stdlib.h>
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include <math.h>
 #include <float.h>
 #include "minc2.h"
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/datatype.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/datatype.c
index d6bf234d2b0..dd3be51b142 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/datatype.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/datatype.c
@@ -3,7 +3,7 @@
  ************************************************************************/
 
 #include <stdlib.h>
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include "minc2.h"
 #include "minc2_private.h"
 
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/grpattr.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/grpattr.c
index 732e5cadc2f..68e736d009f 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/grpattr.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/grpattr.c
@@ -6,7 +6,7 @@
  * Functions to manipulate attributes and groups.
  ************************************************************************/
 #include <stdlib.h>
-#include <hdf5.h>
+#include <itk_hdf5.h>
 
 #ifdef HAVE_CONFIG_H
 #include "config.h"
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/label.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/label.c
index 54da6d1fea7..0eb56afab24 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/label.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/label.c
@@ -13,7 +13,7 @@
  ************************************************************************/
 
 #include <stdlib.h>
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include "minc2.h"
 #include "minc2_private.h"
 
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/m2util.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/m2util.c
index 356224bff3b..93300fa844b 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/m2util.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/m2util.c
@@ -3,7 +3,7 @@
 * \author Leila Baghdadi, Bert Vincent
 *
 ************************************************************************/
-#include <hdf5.h>
+#include <itk_hdf5.h>
 
 #include <stdlib.h>
 #include <math.h>
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/minc2.h b/Modules/ThirdParty/MINC/src/libminc/libsrc2/minc2.h
index d73deb56f87..423d336de97 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/minc2.h
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/minc2.h
@@ -5,7 +5,7 @@
 #ifndef MINC2_H
 #define MINC2_H
 
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include "minc2_defs.h"
 #include "minc2_structs.h"
 #include "minc2_error.h"
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/record.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/record.c
index 40581cf993a..1cf71cb5bb5 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/record.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/record.c
@@ -6,7 +6,7 @@
 #include "config.h"
 #endif /*HAVE_CONFIG_H*/
 
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include "minc2.h"
 #include "minc2_private.h"
 
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/slice.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/slice.c
index ec6e4fcd29a..2758b04dbca 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/slice.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/slice.c
@@ -19,7 +19,7 @@
 #endif /*HAVE_CONFIG_H*/
 
 #include <stdlib.h>
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include "minc2.h"
 #include "minc2_private.h"
 
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/valid.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/valid.c
index 2d99a1df8fa..99329ede576 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/valid.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/valid.c
@@ -14,7 +14,7 @@
 #endif /*HAVE_CONFIG_H*/
 
 #include <stdlib.h>
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include "minc2.h"
 #include "minc2_private.h"
 
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/volprops.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/volprops.c
index c7dc90a7254..e88e9cde210 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/volprops.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/volprops.c
@@ -19,7 +19,7 @@
 
 #define _GNU_SOURCE 1
 #include <stdlib.h>
-#include <hdf5.h>
+#include <itk_hdf5.h>
 #include "minc2.h"
 #include "minc2_private.h"
 #include "minc_config.h"
diff --git a/Modules/ThirdParty/MINC/src/libminc/libsrc2/volume.c b/Modules/ThirdParty/MINC/src/libminc/libsrc2/volume.c
index ecb8cb564d5..dd5751ff433 100644
--- a/Modules/ThirdParty/MINC/src/libminc/libsrc2/volume.c
+++ b/Modules/ThirdParty/MINC/src/libminc/libsrc2/volume.c
@@ -5,7 +5,7 @@
 * Functions to create, open, and close MINC volume objects.
 ************************************************************************/
 #include <stdlib.h>
-#include <hdf5.h>
+#include <itk_hdf5.h>
 
 #ifdef HAVE_CONFIG_H
 #include "config.h"