diff --git a/src/OpenColorIO/Config.cpp b/src/OpenColorIO/Config.cpp
index 1b5a8c70db..89f59eda5d 100644
--- a/src/OpenColorIO/Config.cpp
+++ b/src/OpenColorIO/Config.cpp
@@ -11,6 +11,7 @@
 #include <vector>
 #include <regex>
 #include <functional>
+#include <filesystem>
 
 #include <pystring.h>
 
@@ -1155,7 +1156,7 @@ ConstConfigRcPtr Config::CreateFromFile(const char * filename)
 {
     if (!filename || !*filename)
     {
-        throw ExceptionMissingFile ("The config filepath is missing.");
+        throw ExceptionMissingFile("The config filepath is missing.");
     }
 
     // Check for URI Pattern: ocio://<config name>
@@ -1167,6 +1168,13 @@ ConstConfigRcPtr Config::CreateFromFile(const char * filename)
         return CreateFromBuiltinConfig(uri.c_str());
     }
 
+    if (!std::filesystem::exists(filename))
+    {
+        std::ostringstream oss;
+        oss << "'" << filename << "' file does not exist.";
+        throw ExceptionMissingFile(oss.str().c_str());
+    }
+
     std::ifstream ifstream = Platform::CreateInputFileStream(
         filename, 
         std::ios_base::in | std::ios_base::binary
diff --git a/tests/cpu/builtinconfigs/BuiltinConfig_tests.cpp b/tests/cpu/builtinconfigs/BuiltinConfig_tests.cpp
index c58c3edd24..74a6298efa 100644
--- a/tests/cpu/builtinconfigs/BuiltinConfig_tests.cpp
+++ b/tests/cpu/builtinconfigs/BuiltinConfig_tests.cpp
@@ -446,8 +446,8 @@ OCIO_ADD_TEST(BuiltinConfigs, create_builtin_config)
     // Test that CreateFromFile does not work without ocio:// prefix for built-in config.
     OCIO_CHECK_THROW_WHAT(
         OCIO::Config::CreateFromFile("cg-config-v1.0.0_aces-v1.3_ocio-v2.1"),
-        OCIO::Exception,
-        "Error could not read 'cg-config-v1.0.0_aces-v1.3_ocio-v2.1' OCIO profile."
+        OCIO::ExceptionMissingFile,
+        "'cg-config-v1.0.0_aces-v1.3_ocio-v2.1' file does not exist."
     );    
 
     {
diff --git a/tests/python/ConfigTest.py b/tests/python/ConfigTest.py
index 9debc3da2e..4834f06ac8 100644
--- a/tests/python/ConfigTest.py
+++ b/tests/python/ConfigTest.py
@@ -1011,7 +1011,7 @@ def testFromEnvAndFromFile(uri, numberOfExpectedColorspaces, expectedConfigName)
         nbOfColorspacesForStudioConfig = 55
 
         # Test that CreateFromFile does not work without ocio:// prefix for built-in config.
-        with self.assertRaises(OCIO.Exception) as cm:
+        with self.assertRaises(OCIO.ExceptionMissingFile) as cm:
             OCIO.Config.CreateFromFile(cgConfigName)
 
         # Test CG config.